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22849 Quinidine, Serum (QUIN)

Quinidine, Serum (QUIN)
Test Code: QUINSO
Synonyms/Keywords
Quinidex, Quinidine
Useful For
Assessing and adjusting dosage for optimal therapeutic level.
Assessing toxicity​.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​0.5 mL ​0.25 mL ​
Collection Processing Instructions
​Red top tubes (RTT) should be centrifuged and aliquoted within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​14 days
​Frozen ​28 days
​Ambient ​14 days
Rejection Criteria
​Serum Separator Tube
Gross Hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available
 Methodology/Instrumentation
Mayo Clinic Laboratory​ Monday through Saturday​ ​1-2 days
Kinetic Interaction of Microparticles in Solution (KIMS)
Reference Lab
Mayo Clinic Laboratories
Test Information
Quinidine is indicated for atrial fibrillation and flutter, and life-threatening ventricular arrhythmia. Optimal serum concentrations are in the range of 2.0 to 5.0 mcg/mL, with toxicity apparent at levels of 6.0 mcg/mL or higher. Symptoms of toxicity (cinchonism) include tinnitus, light-headedness, premature ventricular contractions, and atrioventricular block. Gastrointestinal distress is a frequent side effect, which becomes more severe and is associated with nausea and vomiting at higher drug concentrations.
 
The half life of quinidine is 6 to 8 hours. Physiologic processes that generally reduce hepatic metabolism and renal clearance increase serum quinidine levels, while comedication with cytochrome p450 (CYP) enzyme inducers enhances clearance and results in lower blood concentrations.
Reference Range Information
Therapeutic: 2.0-5.0 mcg/mL
Critical value: > or =6.0 mcg/mL
Interpretation
Optimal response to quinidine occurs when the serum level is between 2.0 to 5.0 mcg/mL.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80194 ​ ​ ​ ​
Synonyms/Keywords
Quinidex, Quinidine
Ordering Applications
Ordering Application Description
​COM
 ​Quinidine (QUIN)​
​Cerner ​Quinidine (QUIN)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​0.5 mL ​0.25 mL ​
Collection Processing
​Red top tubes (RTT) should be centrifuged and aliquoted within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​14 days
​Frozen ​28 days
​Ambient ​14 days
Rejection Criteria
​Serum Separator Tube
Gross Hemolysis
Useful For
Assessing and adjusting dosage for optimal therapeutic level.
Assessing toxicity​.
Reference Range Information
Therapeutic: 2.0-5.0 mcg/mL
Critical value: > or =6.0 mcg/mL
Interpretation
Optimal response to quinidine occurs when the serum level is between 2.0 to 5.0 mcg/mL.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available
 Methodology/Instrumentation
Mayo Clinic Laboratory​ Monday through Saturday​ ​1-2 days
Kinetic Interaction of Microparticles in Solution (KIMS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80194 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.