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25027 EBV PCR, Other (LEBV)

EBV PCR, Other (LEBV)
Test Code: EBPCRSO
Synonyms/Keywords
EBV (Epstein-Barr Virus)
EBV Detection by PCR (Polymerase Chain Reaction)
EBV Detection by PCR (Polymerase Chain Reaction), Spinal Fluid
EBV Detection by Real-Time PCR
Epstein-Barr Virus Detection by PCR (Polymerase Chain Reaction
Epstein-Barr Virus Detection by PCR (Polymerase Chain Reaction), CSF
Epstein-Barr Virus Detection by Polymerase Chain Reaction (PCR)
Epstein-Barr Virus Detection by Polymerase Chain Reaction (PCR), CSF
Epstein-Barr Virus Detection by Real-Time PCR
Infectious Mononucleosis
LightCycler EBV
PCR (Polymerase Chain Reaction)
PCR, Epstein-Barr
Useful For
Rapid qualitative detection of Epstein-Barr virus DNA in specimens for laboratory diagnosis of disease due to this virus
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Specimen source is required.
Submit only 1 of the following specimens:
Fluid:  Spinal Fluid, sterile body fluids (peritoneal fluid/ascites, pericaridial fluid, pleural fluid/thoracentesis, amniotic or ocular) ​Sterile container ​0.5 mL 0.3 mL​
​Respiratory:  Bronchial washing, bronchoalveolar lavage, nasopharyngeal aspirate or washing, sputum, or tracheal aspirate Sterile container​ ​1.5 mL ​1.0 mL
Swab: Eye swabs and upper respiratory swabs (nasal, throat) M4-RT, M4 or M5 ​Eswabs
​Bone marrow EDTA Lavender Top Tube (LTT) 0.5 mL
Tissue:  Brain, colon, kidney, liver, lung, etc. ​M4-RT ​Sterile container containing 1 mL or 2 mL of sterile saline or multimicrobe medium (M4-RT, M4 or M5) Entire collection ​2 x 2-mm biopsy
Collection Processing Instructions

​Body fluid: Do not centrifuge.

Bone marrow:  Clotted specimens will be rejected.

Tissue:  Submit only fresh tissue.

Specimen Stability Information
Specimen Type Temperature Time
Body fluid​ ​ ​Refrigerated (preferred) ​7 days
​Frozen ​7 days
​Respiratory ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
​Swab ​​Refrigerated (preferred)​7 days
​Frozen​7 days
Bone marrow​ ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
​Tissue ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
Rejection Criteria
Tissues/SwabsCalcium alginate-tipped swab, wood swab, or transport swab containing gel, Formalin-fixed and paraffin-embedded tissues
Interference

A negative result does not eliminate the possibility of Epstein-Barr virus (EBV) infection of the central nervous system.

This assay may detect viremia or viral shedding in asymptomatic individuals. However, this assay is only to be used for patients with a clinical history and symptoms consistent with EBV infection, and must be interpreted in the context of the clinical picture. This test should not be used to screen asymptomatic patients.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​
2-3 days
Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)​
Reference Lab
Test Information
​Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis, Burkitt's lymphoma, and in Southern China, nasopharyngeal carcinoma. EBV-associated central nervous system (CNS) disease is most commonly associated with primary CNS lymphoma in patients with AIDS. In addition, CNS infection associated with the detection of EBV DNA can be detected in immunocompetent patients.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Negative
Interpretation
Detection of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid (CSF) supports the clinical diagnosis of central nervous system (CNS) disease due to the virus. EBV DNA is not detected in CSF from patients without CNS disease caused by this virus.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​87798
Synonyms/Keywords
EBV (Epstein-Barr Virus)
EBV Detection by PCR (Polymerase Chain Reaction)
EBV Detection by PCR (Polymerase Chain Reaction), Spinal Fluid
EBV Detection by Real-Time PCR
Epstein-Barr Virus Detection by PCR (Polymerase Chain Reaction
Epstein-Barr Virus Detection by PCR (Polymerase Chain Reaction), CSF
Epstein-Barr Virus Detection by Polymerase Chain Reaction (PCR)
Epstein-Barr Virus Detection by Polymerase Chain Reaction (PCR), CSF
Epstein-Barr Virus Detection by Real-Time PCR
Infectious Mononucleosis
LightCycler EBV
PCR (Polymerase Chain Reaction)
PCR, Epstein-Barr
Ordering Applications
Ordering Application Description
​Centricity ​EBV PCR, Other (LEBV)
​Cerner ​Epstein-Barr Virus PCR (81239)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Specimen source is required.
Submit only 1 of the following specimens:
Fluid:  Spinal Fluid, sterile body fluids (peritoneal fluid/ascites, pericaridial fluid, pleural fluid/thoracentesis, amniotic or ocular) ​Sterile container ​0.5 mL 0.3 mL​
​Respiratory:  Bronchial washing, bronchoalveolar lavage, nasopharyngeal aspirate or washing, sputum, or tracheal aspirate Sterile container​ ​1.5 mL ​1.0 mL
Swab: Eye swabs and upper respiratory swabs (nasal, throat) M4-RT, M4 or M5 ​Eswabs
​Bone marrow EDTA Lavender Top Tube (LTT) 0.5 mL
Tissue:  Brain, colon, kidney, liver, lung, etc. ​M4-RT ​Sterile container containing 1 mL or 2 mL of sterile saline or multimicrobe medium (M4-RT, M4 or M5) Entire collection ​2 x 2-mm biopsy
Collection Processing

​Body fluid: Do not centrifuge.

Bone marrow:  Clotted specimens will be rejected.

Tissue:  Submit only fresh tissue.

Specimen Stability Information
Specimen Type Temperature Time
Body fluid​ ​ ​Refrigerated (preferred) ​7 days
​Frozen ​7 days
​Respiratory ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
​Swab ​​Refrigerated (preferred)​7 days
​Frozen​7 days
Bone marrow​ ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
​Tissue ​ ​Refrigerated (preferred) ​7 days
​Frozen​7 days
Rejection Criteria
Tissues/SwabsCalcium alginate-tipped swab, wood swab, or transport swab containing gel, Formalin-fixed and paraffin-embedded tissues
Interference

A negative result does not eliminate the possibility of Epstein-Barr virus (EBV) infection of the central nervous system.

This assay may detect viremia or viral shedding in asymptomatic individuals. However, this assay is only to be used for patients with a clinical history and symptoms consistent with EBV infection, and must be interpreted in the context of the clinical picture. This test should not be used to screen asymptomatic patients.

Useful For
Rapid qualitative detection of Epstein-Barr virus DNA in specimens for laboratory diagnosis of disease due to this virus
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Negative
Interpretation
Detection of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid (CSF) supports the clinical diagnosis of central nervous system (CNS) disease due to the virus. EBV DNA is not detected in CSF from patients without CNS disease caused by this virus.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​
2-3 days
Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​87798
For most current information refer to the Marshfield Laboratory online reference manual.