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25147 Methylphenidate and Metabolite, Urine

Methylphenidate and Metabolite, Urine
Test Code: MPHEND
Synonyms/Keywords
​Ritalin, Concerta, Metadate
Useful For
​Detecting the presence of methylphenidate and its major metabolite, ritalinic acid, in urine to confirm abuse or to monitor compliance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 48 hours​
Refrigerate​ 14 days​
Frozen​ 30 days​
Rejection Criteria
Specimens exposed to repeated freeze/thaw cycles are not acceptable
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday 2-4 days​ Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.

This test is a urine LCMS/MS confirmation for methylphenidate (Ritalin) and its major metabolite, ritalinic acid.   Methylphenidate is prescribed for various disorders such as Attention Deficit Hyperactivity Disorder (ADHD), fatigue, and narcolepsy.  It is a central nervous system stimulant similar in chemical structure and effect to amphetamine.  It can be abused, particularly for relief of fatigue.  It can have a strong stimulating effect on people who use it for non-medical reasons and is very addictive.​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative LCMS/MS result.​
Interpretation

​Current Cutoff Levels for Toxicology

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80360 ​ 1​ Methylphenidate and Metabolite ​
​G0480 ​ ​1 Methylphenidate and Metabolite ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
​Ritalin, Concerta, Metadate
Ordering Applications
Ordering Application Description
​COM ​Methylphenidate, Urine

​Cerner
​​Methylphenidate and Metabolite, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 48 hours​
Refrigerate​ 14 days​
Frozen​ 30 days​
Rejection Criteria
Specimens exposed to repeated freeze/thaw cycles are not acceptable
Useful For
​Detecting the presence of methylphenidate and its major metabolite, ritalinic acid, in urine to confirm abuse or to monitor compliance.
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative LCMS/MS result.​
Interpretation

​Current Cutoff Levels for Toxicology

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday 2-4 days​ Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80360 ​ 1​ Methylphenidate and Metabolite ​
​G0480 ​ ​1 Methylphenidate and Metabolite ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.