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25599 Drug Evaluation, Comprehensive, Urine

Drug Evaluation, Comprehensive, Urine
Test Code: TOXIQL
Synonyms/Keywords
Comprehensive drug screen, amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, ethanol, opiates, opioids, over-the counter, prescription, and illicit drugs.
Test Components
Test performed include:
1) Immunoassay presumptive screen for 11 drug classes, followed by quantitative confirmation by gas and liquid chromatography methods (if needed)
2) Full-scan qualitative time-of-flight liquid chromatography mass spectrometry (LC-MS-QToF) to definitively detect a broad range of drugs that comprises 
168 drugs and covers over 22 classes of over-the-counter, prescription, and illicit drugs encountered in our patient population.
Useful For
The detection of commonly prescribed and over-the-counter medications and most classes of illicit drugs. The test identifies a broad spectrum of drugs and is intended to be used for toxicological evaluation of overdose/intoxication or a baseline drug profile for drug rehabilitation admissions. This test is not useful for compliance monitoring of pain management or drugs of abuse testing.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 10 mL​ 4 mL​ 2 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate (Preferred)​ 30 days​
Ambient​ 7 days​
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 3 days​ Immunoassay by AU680 Chemistry Analyzer with Emit Immunoassay followed by quantitative confirmation by GC-MS, LC-MS-QToF and/or LC-MS/MS, (if needed):  Liquid chromatography time-of-flight separation followed by full spectrum accurate mass spectrometry (LC-MS-QToF) definitive screen.
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 
The test is effective on 09/07/2016.
 
The test detects and identifies a broad range of prescription, over-the-counter, and illicit drugs.
The test includes the following components:
1) Presumptive Immunoassay screen for 11 classes of drugs: ethanol, cannabinoids, cocaine, amphetamines, ecstasy, barbiturates, benzodiazepines, opiates, oxycodone, methadone, and buprenorphine with reflexed quantitative confirmatory testing by GC-MS, LC-MS-QToF and/or LC-MS/MS method confirmation upon a positive immunoassay screen. Quantitative ethanol testing perfomed by Immunoassay
2) Urine creatinine and pH (i.e. "specimen validity tests")
3) Liquid chromatography separation followed by full spectrum accurate mass scan by liquid chromatography with time-of-flight accurate mass spectrometry (LC-MS-QToF) ​definitive screen to detect and identify 168 drugs.  Please click the following link to view the list of drugs detected by this definitive screening method:
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative​
Interpretation

Current Cutoff Levels for Toxicology

For detailed interpretation information of each drug class/group, please refer to the individual test codes.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80307​ 1 Drug test, presumptive, immunoassay by insturmented chemistry analyzer to screen 11 classes of drugs
G0480 ​1 Drug test, definitive and qualitative, by LC-MS-QToF high accurate mass spectrometry to scan 168 drugs, over 22 classes, in a confirmed and verified drug library
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
Comprehensive drug screen, amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, ethanol, opiates, opioids, over-the counter, prescription, and illicit drugs.
Test Components
Test performed include:
1) Immunoassay presumptive screen for 11 drug classes, followed by quantitative confirmation by gas and liquid chromatography methods (if needed)
2) Full-scan qualitative time-of-flight liquid chromatography mass spectrometry (LC-MS-QToF) to definitively detect a broad range of drugs that comprises 
168 drugs and covers over 22 classes of over-the-counter, prescription, and illicit drugs encountered in our patient population.
Ordering Applications
Ordering Application Description
​Centricity ​Drug Scn, Comprehensive-Ur
​Cerner ​Drug Screen Urine, Quant
​COM ​Toxicology Eval, Comp, Ur
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 10 mL​ 4 mL​ 2 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate (Preferred)​ 30 days​
Ambient​ 7 days​
Frozen​ 30 days​
Useful For
The detection of commonly prescribed and over-the-counter medications and most classes of illicit drugs. The test identifies a broad spectrum of drugs and is intended to be used for toxicological evaluation of overdose/intoxication or a baseline drug profile for drug rehabilitation admissions. This test is not useful for compliance monitoring of pain management or drugs of abuse testing.
Test Components
Test performed include:
1) Immunoassay presumptive screen for 11 drug classes, followed by quantitative confirmation by gas and liquid chromatography methods (if needed)
2) Full-scan qualitative time-of-flight liquid chromatography mass spectrometry (LC-MS-QToF) to definitively detect a broad range of drugs that comprises 
168 drugs and covers over 22 classes of over-the-counter, prescription, and illicit drugs encountered in our patient population.
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative​
Interpretation

Current Cutoff Levels for Toxicology

For detailed interpretation information of each drug class/group, please refer to the individual test codes.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 3 days​ Immunoassay by AU680 Chemistry Analyzer with Emit Immunoassay followed by quantitative confirmation by GC-MS, LC-MS-QToF and/or LC-MS/MS, (if needed):  Liquid chromatography time-of-flight separation followed by full spectrum accurate mass spectrometry (LC-MS-QToF) definitive screen.
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80307​ 1 Drug test, presumptive, immunoassay by insturmented chemistry analyzer to screen 11 classes of drugs
G0480 ​1 Drug test, definitive and qualitative, by LC-MS-QToF high accurate mass spectrometry to scan 168 drugs, over 22 classes, in a confirmed and verified drug library
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.