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22212 Alpha-1 Antitrypsin

Alpha-1 Antitrypsin
Test Code: AAT
Synonyms/Keywords
AAT, Alpha-1-antitrypsin, Alpha trypsin inhibitor, Alpha-1-protease inhibitor​
Useful For
The principle clinical interest in AAT levels is in detecting genetic deficiencies that lead to a form of emphysema. Proteolytic enzymes are released by bacteria and other inflammatory cells which are not inhibited and which cause tissue destruction in individuals with AAT deficiency.  If decreased levels are found in individuals with pulmonary disease, genetic phenotyping using starch gel electrophoresis is frequently performed.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Serum​
Red Top Tube
(RTT)​
 Serum Separator Tube (SST)​ 0.5 mL ​ 0.4 mL 0.3 mL
Specimen Stability Information
Specimen Type Temperature

Time

Serum​ Refrigerate​ 7 days​
Frozen 3 months
Rejection Criteria
Plasma samples
Interference
Pregnancy and oral contraceptives may cause increase in Alpha-1 Antitrypsin​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
Reference Range Information
Performing Location Reference Range
Marshfield​ 90 - 200 mg/dL​
Interpretation
Less than 80 mg/dL is considered clinically at risk for AAT deficiency. Follow-up AAT genotyping (A1ALCSO) is recommended.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82103​ ​ ​ ​ ​
Synonyms/Keywords
AAT, Alpha-1-antitrypsin, Alpha trypsin inhibitor, Alpha-1-protease inhibitor​
Ordering Applications
Ordering Application Description
​Cerner Alpha-​1-Antitrypsin
​COM ​Alpha-1-Antitrypsin

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Serum​
Red Top Tube
(RTT)​
 Serum Separator Tube (SST)​ 0.5 mL ​ 0.4 mL 0.3 mL
Specimen Stability Information
Specimen Type Temperature

Time

Serum​ Refrigerate​ 7 days​
Frozen 3 months
Rejection Criteria
Plasma samples
Interference
Pregnancy and oral contraceptives may cause increase in Alpha-1 Antitrypsin​
Useful For
The principle clinical interest in AAT levels is in detecting genetic deficiencies that lead to a form of emphysema. Proteolytic enzymes are released by bacteria and other inflammatory cells which are not inhibited and which cause tissue destruction in individuals with AAT deficiency.  If decreased levels are found in individuals with pulmonary disease, genetic phenotyping using starch gel electrophoresis is frequently performed.
Reference Range Information
Performing Location Reference Range
Marshfield​ 90 - 200 mg/dL​
Interpretation
Less than 80 mg/dL is considered clinically at risk for AAT deficiency. Follow-up AAT genotyping (A1ALCSO) is recommended.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82103​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.