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22215 Alpha-2-Macroglobulin, Serum (A2M)

Alpha-2-Macroglobulin, Serum (A2M)
Test Code: MISC
Synonyms/Keywords
AMG (Alpha-2-Macroglobulin), AMG, macroglobulin, Macroglobulin, Alpha-2
Useful For
​Evaluation of patients with nephrotic syndrome and pancreatitis
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 21 days​
Frozen ​ 28 days​
Ambient ​ 72 hours​
Rejection Criteria
Gross lipemia
Interference

​Quantitation of specific proteins by nephelometric means may not be possible in lipemic sera due to the extreme light scattering properties of the specimen. Turbidity and particles in the specimen may result in extraneous light scattering signals, resulting in variable specimen analysis.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​
1 to 2 days
Nephelometry​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information

< or =18 years: 178-495 mg/dL

>18 years: 100-280 mg/dL

Interpretation
​Values are elevated in the nephrotic syndrome in proportion to the severity of protein loss (lower molecular weight).  
 
Values are low in proteolytic diseases such as pancreatitis.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83883 ​ ​ ​ ​
Synonyms/Keywords
AMG (Alpha-2-Macroglobulin), AMG, macroglobulin, Macroglobulin, Alpha-2
Ordering Applications
Ordering Application Description
​COM ​Misc Test
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 21 days​
Frozen ​ 28 days​
Ambient ​ 72 hours​
Rejection Criteria
Gross lipemia
Interference

​Quantitation of specific proteins by nephelometric means may not be possible in lipemic sera due to the extreme light scattering properties of the specimen. Turbidity and particles in the specimen may result in extraneous light scattering signals, resulting in variable specimen analysis.

Useful For
​Evaluation of patients with nephrotic syndrome and pancreatitis
Reference Range Information

< or =18 years: 178-495 mg/dL

>18 years: 100-280 mg/dL

Interpretation
​Values are elevated in the nephrotic syndrome in proportion to the severity of protein loss (lower molecular weight).  
 
Values are low in proteolytic diseases such as pancreatitis.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​
1 to 2 days
Nephelometry​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83883 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.