Skip Ribbon Commands
Skip to main content
Sign In
Navigate Up

22306 Centromere Antibodies

Centromere Antibodies
Test Code: CENTB
Synonyms/Keywords
​Centromere Antibody, Antinuclear Antibody, ANA​
Useful For
There is an association between centromere antibodies and the clinical CREST (Calcinosis, Raynaud's phenomenon, esophageal disfunction, sclerodactyly, telangictasia) syndrome, considered to be a milder form of scleroderma.​

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube (RTT) or Serum Separator Tube (SST) ​
 ​ 1.0 mL​ 0.4 mL 0.3 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen 6 months​
Rejection Criteria
Gross lipemia 
Gross hemolysis​
Heat inactivated samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marsfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
 Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 - 8.0 AI (Antibody Index). ​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
Synonyms/Keywords
​Centromere Antibody, Antinuclear Antibody, ANA​
Ordering Applications
Ordering Application Description
​Cerner ​Centromere Antibodies
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube (RTT) or Serum Separator Tube (SST) ​
 ​ 1.0 mL​ 0.4 mL 0.3 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen 6 months​
Rejection Criteria
Gross lipemia 
Gross hemolysis​
Heat inactivated samples​
Useful For
There is an association between centromere antibodies and the clinical CREST (Calcinosis, Raynaud's phenomenon, esophageal disfunction, sclerodactyly, telangictasia) syndrome, considered to be a milder form of scleroderma.​

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Reference Range Information
Performing Location Reference Range
 Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 - 8.0 AI (Antibody Index). ​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marsfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.