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22310 Double Stranded DNA Antibodies

Double Stranded DNA Antibodies
Test Code: DSDNA
Synonyms/Keywords
Anti-DNA, DNA antibodies, native DNA​
Useful For
DsDNA antibodies are characteristic markers in Systemic Lupus Erythematosus (SLE). This antibody is found in 60–70% of SLE patients. Low levels of dsDNA have been indicated in rheumatic disease patients and as a precursor to disease recognition.​

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
Marshfield​
< or =4 IU/mL: Negative
5 - 9 IU/mL: Indeterminate
> or =10 IU/mL: Positive
Analytical measuring range is 1 -300 IU/mL​
Interpretation

​A positive result supports the diagnosis of systemic lupus erythematosus.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86225​ ​ ​ ​ ​
Synonyms/Keywords
Anti-DNA, DNA antibodies, native DNA​
Ordering Applications
Ordering Application Description
​Centricity ​Double Stranded DNA Abs
​Cerner ​DNA Antibody (Double-stranded) IgG
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia​
Useful For
DsDNA antibodies are characteristic markers in Systemic Lupus Erythematosus (SLE). This antibody is found in 60–70% of SLE patients. Low levels of dsDNA have been indicated in rheumatic disease patients and as a precursor to disease recognition.​

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Reference Range Information
Performing Location Reference Range
Marshfield​
< or =4 IU/mL: Negative
5 - 9 IU/mL: Indeterminate
> or =10 IU/mL: Positive
Analytical measuring range is 1 -300 IU/mL​
Interpretation

​A positive result supports the diagnosis of systemic lupus erythematosus.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86225​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.