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22468 Copper, 24 Hour, Urine (CUU)

Copper, 24 Hour, Urine (CUU)
Test Code: COPURSO
Synonyms/Keywords

​Copper (Cu), Wilson's Disease, Wilson Disease

Copper,24 Hour Urine (CUU)

U COPURSO

Useful For
Investigation of Wilson disease and obstructive liver disease using a 24-hour urine specimen
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
24-Hour Urine​ Plastic, 10-mL urine tube ​ Clean, plastic aliquot container with no metal cap or glued insert​ 10 mL​ 0.4 mL​ ​
Collection Processing Instructions
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
Additional Information:
1. 24-Hour volume is required.
2. High concentrations of barium are known to interfere with this test. If barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.
3. See Mayo Labs website for additional information regarding acceptable preservatives and collection details. 
Acceptable Specimen Types
​24-Hour volume is required.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ ​ Refrigerated (preferred)​ 28 days​
​Ambient ​28 days
​Frozen ​28 days
Rejection Criteria
​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday
 1  to 6 day​s
Inductively Coupled Plasma-Mass Spectrometry
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​​
0-17 years: not established
> or =18 years: 9-71 mcg/24h
Interpretation
​
Humans normally excrete <60 mcg/day of copper in the urine.
 
Urinary copper excretion >60 mcg/day may be seen in:
-Wilson disease
-Obstructive biliary disease (eg, primary biliary cirrhosis, primary sclerosing cholangitis)
-Nephrotic syndrome (due to leakage through the kidney)
-Chelation therapy
-Estrogen therapy
-Mega-dosing of zinc-containing vitamins
 
Because ceruloplasmin is an acute phase reactant, urine copper is elevated during acute inflammation. During the recovery phase, urine copper is usually below normal, reflecting the expected physiologic response to replace the copper that was depleted during inflammation.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82525 ​ ​ ​ ​
Synonyms/Keywords

​Copper (Cu), Wilson's Disease, Wilson Disease

Copper,24 Hour Urine (CUU)

U COPURSO

Ordering Applications
Ordering Application Description
​COM ​Copper, 24 Hr Urine (CUU)
​Cerner Copper,24 Hour Urine (CUU)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
24-Hour Urine​ Plastic, 10-mL urine tube ​ Clean, plastic aliquot container with no metal cap or glued insert​ 10 mL​ 0.4 mL​ ​
Collection Processing
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
Additional Information:
1. 24-Hour volume is required.
2. High concentrations of barium are known to interfere with this test. If barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.
3. See Mayo Labs website for additional information regarding acceptable preservatives and collection details. 
Acceptable Specimen Types
​24-Hour volume is required.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ ​ Refrigerated (preferred)​ 28 days​
​Ambient ​28 days
​Frozen ​28 days
Rejection Criteria
​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Useful For
Investigation of Wilson disease and obstructive liver disease using a 24-hour urine specimen
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​​
0-17 years: not established
> or =18 years: 9-71 mcg/24h
Interpretation
​
Humans normally excrete <60 mcg/day of copper in the urine.
 
Urinary copper excretion >60 mcg/day may be seen in:
-Wilson disease
-Obstructive biliary disease (eg, primary biliary cirrhosis, primary sclerosing cholangitis)
-Nephrotic syndrome (due to leakage through the kidney)
-Chelation therapy
-Estrogen therapy
-Mega-dosing of zinc-containing vitamins
 
Because ceruloplasmin is an acute phase reactant, urine copper is elevated during acute inflammation. During the recovery phase, urine copper is usually below normal, reflecting the expected physiologic response to replace the copper that was depleted during inflammation.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday
 1  to 6 day​s
Inductively Coupled Plasma-Mass Spectrometry
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82525 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.