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22577 EBV Comprehensive Antibody Panel

EBV Comprehensive Antibody Panel
Test Code: EBVCOMP
Synonyms/Keywords
Epstein Barr Virus, Early antigen, VCA, nuclear antigen, EBV, Viral Capsid Antigen​
Test Components
Epstein Barr virus (EBV) Viral capsid antigen IgG and IgM; EBV early antigen D IgG; EBV nuclear antigen IgG.  ​
Useful For
The serological diagnosis of EBV-related diseases is based upon the detection of antibodies to the EBV VCA, NA and EA antigens (as well as the Paul-Bunnell heterophile antibody). This test should be considered as an aid in the diagnosis of EBV-related chronic and reactivation diseases such as Burkitt's lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disease (PTLD).
The detection of Paul-Bunnell heterophile antibody is normally sufficient for the diagnosis of infectious mononucleosis (IM), the most common form of EBV disease; the detection of anti-VCA antibodies alone may also be used in cases of suspected Monospot-negative IM. See Infectious Mononucleosis (IM) and EBV Viral Capsid Antigen IgM & IgG Antibodies (EBVCGM) respectively for information on these tests. Detection of anti-NA and anti-EA is rarely necessary for the diagnosis of IM.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.5 mL​ 0.2 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.​

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Hemolyzed specimens
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
Marshfield ​ Negative​
Interpretation
Note that these interpretations are of a general nature, and exceptions exist. Consultation with an infectious diseases specialist should be considered when diagnosing suspected chronic EBV disease.
Primary IM: VCA IgM+ / VCA IgG+ / EA IgG+ / NA IgG-
Late IM: VCA IgM+ / VCA IgG+ / EA IgG+ / NA IgG usually-
Recovery: VCA IgM- / VCA IgG+ / EA IgG usually- / NA IgG+
Latency: VCA IgM- / VCA IgG+ / EA IgG- / NA IgG+
Reactivation: VCA IgM may reappear / VCA IgG+ / EA IgG may reappear / NA IgG+
(+ indicates antibody may or may not be present) ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86665​ ​ ​2 EBV Viral Capsid IgG and IgM​ ​
86664​ ​ ​1 EBV nuclear antigen-1​ ​
86663​ ​ ​1 EBV Early Antigen-D​ ​
Synonyms/Keywords
Epstein Barr Virus, Early antigen, VCA, nuclear antigen, EBV, Viral Capsid Antigen​
Test Components
Epstein Barr virus (EBV) Viral capsid antigen IgG and IgM; EBV early antigen D IgG; EBV nuclear antigen IgG.  ​
Ordering Applications
Ordering Application Description
​Centricity ​EBV Comprehensive Ab Panel
​Cerner ​EBV Comprehensive Antibody Panel
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.5 mL​ 0.2 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.​

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Hemolyzed specimens
Useful For
The serological diagnosis of EBV-related diseases is based upon the detection of antibodies to the EBV VCA, NA and EA antigens (as well as the Paul-Bunnell heterophile antibody). This test should be considered as an aid in the diagnosis of EBV-related chronic and reactivation diseases such as Burkitt's lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disease (PTLD).
The detection of Paul-Bunnell heterophile antibody is normally sufficient for the diagnosis of infectious mononucleosis (IM), the most common form of EBV disease; the detection of anti-VCA antibodies alone may also be used in cases of suspected Monospot-negative IM. See Infectious Mononucleosis (IM) and EBV Viral Capsid Antigen IgM & IgG Antibodies (EBVCGM) respectively for information on these tests. Detection of anti-NA and anti-EA is rarely necessary for the diagnosis of IM.​
Test Components
Epstein Barr virus (EBV) Viral capsid antigen IgG and IgM; EBV early antigen D IgG; EBV nuclear antigen IgG.  ​
Reference Range Information
Performing Location Reference Range
Marshfield ​ Negative​
Interpretation
Note that these interpretations are of a general nature, and exceptions exist. Consultation with an infectious diseases specialist should be considered when diagnosing suspected chronic EBV disease.
Primary IM: VCA IgM+ / VCA IgG+ / EA IgG+ / NA IgG-
Late IM: VCA IgM+ / VCA IgG+ / EA IgG+ / NA IgG usually-
Recovery: VCA IgM- / VCA IgG+ / EA IgG usually- / NA IgG+
Latency: VCA IgM- / VCA IgG+ / EA IgG- / NA IgG+
Reactivation: VCA IgM may reappear / VCA IgG+ / EA IgG may reappear / NA IgG+
(+ indicates antibody may or may not be present) ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86665​ ​ ​2 EBV Viral Capsid IgG and IgM​ ​
86664​ ​ ​1 EBV nuclear antigen-1​ ​
86663​ ​ ​1 EBV Early Antigen-D​ ​
For most current information refer to the Marshfield Laboratory online reference manual.