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22709 Hepatitis B Core Antibody, Total

Hepatitis B Core Antibody, Total
Test Code: ABC
Synonyms/Keywords
Anti-HB Core, HB Core AB, Anti-HBc​
Useful For
To aid in the diagnosis of hepatitis B and determining the phase of a hepatitis B infection.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL​0.3 mL​
Collection Processing Instructions
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites:  Please send samples to Marshfield frozen. 

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Ambient​ <8 hours​
Refrigerate​ <48 hours​
Frozen​ at -20 °C 6 months​
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Microparticle Chemiluminometric Immunoassay/Siemens Centaur  ​
Test Information

Hepatitis B is a viral illness that is transmitted through blood and other body fluids. Both acute and chronic stages occur, with the frequency of progression to chronicity declining with age at time of infection. Chronic hepatitis B often leads to cirrhosis and hepatocellular carcinoma. Hepatitis B is a vaccine-preventable disease.

Limitations
• The results determined by different assays from different manufacturers can vary due to differences in assay specificities and cannot be used interchangeably.
• The performance of the assay has not been established with cord blood, neonatal specimens, infants, children, or adolescent patients, immunocompromised, immunosuppressed, cadaver specimens, heat-inactivated specimens, or body fluids.
• A reactive Anti-Hepatitis B core Total result does not exclude co-infection by another hepatitis virus.

Reference Range Information
Performing Location Reference Range
Marshfield​ Reported as "Reactive" or "Non-reactive"​
Interpretation

The presence of hepatitis B core total antibody is consistent with both acute and chronic hepatitis B. The HEPATITIS B CORE ANTIBODY, IgM (test code ABC-M) may be used to resolve these two phases.

A result of a single hepatitis B lab study should be interpreted with caution.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86704​ ​ ​ ​ ​
Synonyms/Keywords
Anti-HB Core, HB Core AB, Anti-HBc​
Ordering Applications
Ordering Application Description
​Centricity Hepatitis B Core Ab (Anti-HB Core)​
​Cerner Heptiatis B Core Antibody, Total​
​Clinical Order Manager ​Hepatitis B Core Antibody
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL​0.3 mL​
Collection Processing
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites:  Please send samples to Marshfield frozen. 

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Ambient​ <8 hours​
Refrigerate​ <48 hours​
Frozen​ at -20 °C 6 months​
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
Useful For
To aid in the diagnosis of hepatitis B and determining the phase of a hepatitis B infection.
Reference Range Information
Performing Location Reference Range
Marshfield​ Reported as "Reactive" or "Non-reactive"​
Interpretation

The presence of hepatitis B core total antibody is consistent with both acute and chronic hepatitis B. The HEPATITIS B CORE ANTIBODY, IgM (test code ABC-M) may be used to resolve these two phases.

A result of a single hepatitis B lab study should be interpreted with caution.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Microparticle Chemiluminometric Immunoassay/Siemens Centaur  ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86704​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.