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22785 CSF IgG

CSF IgG
Test Code: IGG-CSF
Synonyms/Keywords
Immunoglobulin G in spinal fluid; Immunoglobulin G, CSF​
Test Components
CSF IgG, CSF Albumin, Total Protein​
Useful For
Measurement of the CSF proteins, albumin and IgG, are directed mainly towards the demonstration of two common disorders, namely blood-brain barrier damage and selective elevation of IgG due to local synthesis within the CNS.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Spinal Fluid (CSF)​ Spinal fluid collection tube​ Plastic tube​ 1.0 mL​ 0.5 mL​ ​0.5 mL
Collection Processing Instructions
​Collection must be made with no red blood cells (RBC)
Specimen Stability Information
Specimen Type Temperature Time
CSF Refrigerated​ 7 days​
Rejection Criteria
Hemolysis and/or the presence of intact RBC’s in the CSF specimen
Frozen samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
Test Information
Hemolysis and/or the presence of intact RBC’s in the CSF specimen will elevate both the CSF albumin and IgG because of serum contamination.​
Reference Range Information


​Performing Location
​Reference Range
​​​





Marshfield
​ ​ ​
​Total Protein (CSF) 0-1 month: 30-90 mg/dL
​Total Protein (CSF) 1 month-adult: 15-45 mg/dL
​IgG (CSF): 0-6.6 mg/dL
​Albumin (CSF): 15-32 mg/dL
​IgG/Albumin ratio: 0.00-0.27

Interpretation
An increase in the CSF IgG with a corresponding increase in the CSF IgG/Albumin Ratio suggests that the IgG is produced locally. Increases of IgG and total protein without corresponding increases in the ratio indicate damage to the blood-brain barrier.
In rare instances, the CSF albumin can be elevated and the IgG normal. This can mean the blood-brain barrier has become permeable to albumin, but not IgG, which is a larger molecule. Guillian-Barre Syndrome, which has been associated with influenza immunization shots, will give similar results. The total protein will also be elevated in this syndrome. The difference here is that the albumin is derived from breakdown of the CNS tissues.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​
 ​
 ​
 ​
82042​
​
​
​
​
​84157
​​​​
Synonyms/Keywords
Immunoglobulin G in spinal fluid; Immunoglobulin G, CSF​
Test Components
CSF IgG, CSF Albumin, Total Protein​
Ordering Applications
Ordering Application Description
​Cerner
IGG-CSF​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Spinal Fluid (CSF)​ Spinal fluid collection tube​ Plastic tube​ 1.0 mL​ 0.5 mL​ ​0.5 mL
Collection Processing
​Collection must be made with no red blood cells (RBC)
Specimen Stability Information
Specimen Type Temperature Time
CSF Refrigerated​ 7 days​
Rejection Criteria
Hemolysis and/or the presence of intact RBC’s in the CSF specimen
Frozen samples​
Useful For
Measurement of the CSF proteins, albumin and IgG, are directed mainly towards the demonstration of two common disorders, namely blood-brain barrier damage and selective elevation of IgG due to local synthesis within the CNS.​
Test Components
CSF IgG, CSF Albumin, Total Protein​
Reference Range Information


​Performing Location
​Reference Range
​​​





Marshfield
​ ​ ​
​Total Protein (CSF) 0-1 month: 30-90 mg/dL
​Total Protein (CSF) 1 month-adult: 15-45 mg/dL
​IgG (CSF): 0-6.6 mg/dL
​Albumin (CSF): 15-32 mg/dL
​IgG/Albumin ratio: 0.00-0.27

Interpretation
An increase in the CSF IgG with a corresponding increase in the CSF IgG/Albumin Ratio suggests that the IgG is produced locally. Increases of IgG and total protein without corresponding increases in the ratio indicate damage to the blood-brain barrier.
In rare instances, the CSF albumin can be elevated and the IgG normal. This can mean the blood-brain barrier has become permeable to albumin, but not IgG, which is a larger molecule. Guillian-Barre Syndrome, which has been associated with influenza immunization shots, will give similar results. The total protein will also be elevated in this syndrome. The difference here is that the albumin is derived from breakdown of the CNS tissues.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​
 ​
 ​
 ​
82042​
​
​
​
​
​84157
​​​​
For most current information refer to the Marshfield Laboratory online reference manual.