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23014 Syphilis, Antibody Screen, Routine

Syphilis, Antibody Screen, Routine
Test Code: SYPHAB
Synonyms/Keywords
Syphilis Screen, Treponema pallidum, VDRL​, RPR
Test Components
Syphilis Treponemal - Total Antibody Screen
Rapid Plasma Reagin (RPR) (if needed)
Treponemal Particle agglutination (TPPA) ( if needed)​
Useful For
This test is for screening/diagnostic purposes. For therapeutic monitoring order RPR, Therapeutic Monitoring (RPRTM).
Samples will be tested for IgG and IgM antibodies to Treponemal pallidum. Positive screens will reflex to the RPR (Rapid Plasma Reagin) test at an additional charge. In case the results of the IgG/IgM antibody testing disagree with the RPR, another treponemal test, Treponemal pallidum Particle Agglutination (TPPA) will be performed at an additional charge.
 
NOTE: The CDC and WHO recommend both a positive antibody test against the causative agent Treponema pallidum and a positive non-treponemal test such as the Rapid Plasma Reagin (RPR) before making a serological diagnosis of syphilis.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen​ > 7 days​
Rejection Criteria
​Gross hemolysis
​Gross icteric
​Gross lipemic
​Heat inactivated


Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
Marshfield​ ​Negative
Interpretation
Link to: Syphilis Testing Algorithm​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86780​ ​ 1​ Syphilis, treponemal ​
86593 ​ 1​ RPR (if needed)​ ​
86780​ ​ ​1 ​TP-PA (if needed) ​
Synonyms/Keywords
Syphilis Screen, Treponema pallidum, VDRL​, RPR
Test Components
Syphilis Treponemal - Total Antibody Screen
Rapid Plasma Reagin (RPR) (if needed)
Treponemal Particle agglutination (TPPA) ( if needed)​
Ordering Applications

Ordering Application Description
​Cerner ​Syphilis, Ab Screen, Routine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen​ > 7 days​
Rejection Criteria
​Gross hemolysis
​Gross icteric
​Gross lipemic
​Heat inactivated


Useful For
This test is for screening/diagnostic purposes. For therapeutic monitoring order RPR, Therapeutic Monitoring (RPRTM).
Samples will be tested for IgG and IgM antibodies to Treponemal pallidum. Positive screens will reflex to the RPR (Rapid Plasma Reagin) test at an additional charge. In case the results of the IgG/IgM antibody testing disagree with the RPR, another treponemal test, Treponemal pallidum Particle Agglutination (TPPA) will be performed at an additional charge.
 
NOTE: The CDC and WHO recommend both a positive antibody test against the causative agent Treponema pallidum and a positive non-treponemal test such as the Rapid Plasma Reagin (RPR) before making a serological diagnosis of syphilis.
Test Components
Syphilis Treponemal - Total Antibody Screen
Rapid Plasma Reagin (RPR) (if needed)
Treponemal Particle agglutination (TPPA) ( if needed)​
Reference Range Information
Performing Location Reference Range
Marshfield​ ​Negative
Interpretation
Link to: Syphilis Testing Algorithm​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86780​ ​ 1​ Syphilis, treponemal ​
86593 ​ 1​ RPR (if needed)​ ​
86780​ ​ ​1 ​TP-PA (if needed) ​
For most current information refer to the Marshfield Laboratory online reference manual.