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23109 B-Type Natriuretic Peptide

B-Type Natriuretic Peptide
Test Code: BNP
Synonyms/Keywords
​BNP, Brain-type Natriuretic peptide
Useful For
​This test is used as an aid in the diagnosis of congestive heart failure.
Specimen Requirements
 
​Fasting Required
 Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​

Plasma​

 

(Performing Site-Marshfield Center Lab)

EDTA Pink Top Tube (PTT)​EDTA Lavender Top Tube (LTT)​1.0 mL​ Plasma
0.5 mL​
Plasma
0.3 mL​
Plasma
​No

​Whole Blood

 

(Performing Site-Marshfield Regional Center Labs)

​EDTA Pink Top Tube (PTT)​​EDTA Lavender Top Tube (LTT)​
​1.0 mL
Whole Blood
​0.5 mL
Whole Blood
​0.3 mL
Whole Blood
Collection Processing Instructions

Marshfield Center Lab: Plasma must be separated from red cells within 7 hours of collection. If assay cannot not be performed within 7 hours, plasma may be stored up to 24 hours refrigerated, or at -20 degrees Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25 degrees C may be used to obtain the plasma sample.

Regional Center Labs: Whole blood must be analyzed within 7 hours of collection. If assay cannot not be performed within 7 hours of collection, then centrifuge and remove plasma within 7 hours of collection, and send to Marshfield Center lab for testing. Plasma may be stored up to 24 hours refrigerated, or at -20 degrees Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25 degrees C may be used to obtain the plasma sample.

Specimen Stability Information
Specimen Type Temperature Time
EDTA Whole Blood​ Ambient​ 7 hours
Refrigerate 7 hours
EDTA Plasma​ ​ ​ Ambient 7 hours
​Refrigerate ​24 hours
​Frozen at -20 deg Celsius ​> 24 hours (up to 3 months)
Rejection Criteria
​
Whole Blood > 7 hours
Room Temperature Plasma > 7 hours
Refrigerated Plasma > 24 hours
Interference
​Hemolyzed specimens should be avoided whenever possible. However, hemoglobin (up to 500 mg/dL), triglycerides (triolein up to 3000 mg/dL), bilirubin (up to 20 mg/dL) or human serum albumin (up to 1500 mg/L) do not interfere with the recovery of BNP per Biosite literature.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Chippewa Falls​ ​Monday through Friday ​Less than 2 hours​ ​Fluorescence Immunoassay/Triage Meter Alere
​Weston
 ​Monday through Sunday​ ​Less than 2 hours​ ​​Fluorescence Immunoassay/Triage Meter Alere
​Eau Claire ​Monday through Sunday​ ​Less than 2 hours​ ​​two-step immunoenzymatic assay/Beckman access2/DXI
Park Falls​
 ​Monday through Sunday​ ​Less than 2 hours​ ​​two-step immunoenzymatic assay/Beckman access2/DXI
​Ladysmith Medical Center ​​Monday through Sunday ​Less than 2 hours​ ​​​​two-step immunoenzymatic assay/Beckman access2/DXI​
Marshfield​ Monday through Sunday​ Less than 2 hours​ two-step immunoenzymatic assay/​Beckman DXI 
Minocqua​ ​Monday through Sunday​ ​Less than 2 hours​ ​​​​two-step immunoenzymatic assay/Beckman access2/DXI
​Neillsville​Monday through Sunday​​Less than 2 hours​​Fluorescence Immunoassay/Triage Meter Alere
Rice Lake​​
​Monday through Sunday​
​​Less than 2 hours
​​​two-step immunoenzymatic assay/Beckman access2/DXI
Stevens Point​​Monday through Sunday​​Less than 2 hours​​​​​​​​two-step immunoenzymatic assay/Beckman access2/DXI​ 
​Wisconsin Rapids ​Monday through Sunday ​Less than 2 hours ​Fluorescence Immunoassay/Triage Meter Alere
Reference Range Information

All Performing sites <=100 pg/mL

Interpretation
​Normal values < = 100 pg/mL 
BNP results greater than 100 pg/mL are considered abnormal and suggestive of patients with CHF.  The following interpretative comment is added to all results:

>100 to <200 pg/mL: Likely compensated congestive heart failure (CHF)
200 to 400 pg/mL: Likely moderate CHF
>400 pg/mL: Likely moderate to severe CHF
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83880​ ​ ​ ​ ​
Synonyms/Keywords
​BNP, Brain-type Natriuretic peptide
Ordering Applications

Ordering Application Description
​Cerner
 ​B-Type Natriuretic Peptide 

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
 
​Fasting Required
 Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​

Plasma​

 

(Performing Site-Marshfield Center Lab)

EDTA Pink Top Tube (PTT)​EDTA Lavender Top Tube (LTT)​1.0 mL​ Plasma
0.5 mL​
Plasma
0.3 mL​
Plasma
​No

​Whole Blood

 

(Performing Site-Marshfield Regional Center Labs)

​EDTA Pink Top Tube (PTT)​​EDTA Lavender Top Tube (LTT)​
​1.0 mL
Whole Blood
​0.5 mL
Whole Blood
​0.3 mL
Whole Blood
Collection Processing

Marshfield Center Lab: Plasma must be separated from red cells within 7 hours of collection. If assay cannot not be performed within 7 hours, plasma may be stored up to 24 hours refrigerated, or at -20 degrees Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25 degrees C may be used to obtain the plasma sample.

Regional Center Labs: Whole blood must be analyzed within 7 hours of collection. If assay cannot not be performed within 7 hours of collection, then centrifuge and remove plasma within 7 hours of collection, and send to Marshfield Center lab for testing. Plasma may be stored up to 24 hours refrigerated, or at -20 degrees Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25 degrees C may be used to obtain the plasma sample.

Specimen Stability Information
Specimen Type Temperature Time
EDTA Whole Blood​ Ambient​ 7 hours
Refrigerate 7 hours
EDTA Plasma​ ​ ​ Ambient 7 hours
​Refrigerate ​24 hours
​Frozen at -20 deg Celsius ​> 24 hours (up to 3 months)
Rejection Criteria
​
Whole Blood > 7 hours
Room Temperature Plasma > 7 hours
Refrigerated Plasma > 24 hours
Interference
​Hemolyzed specimens should be avoided whenever possible. However, hemoglobin (up to 500 mg/dL), triglycerides (triolein up to 3000 mg/dL), bilirubin (up to 20 mg/dL) or human serum albumin (up to 1500 mg/L) do not interfere with the recovery of BNP per Biosite literature.
Useful For
​This test is used as an aid in the diagnosis of congestive heart failure.
Reference Range Information

All Performing sites <=100 pg/mL

Interpretation
​Normal values < = 100 pg/mL 
BNP results greater than 100 pg/mL are considered abnormal and suggestive of patients with CHF.  The following interpretative comment is added to all results:

>100 to <200 pg/mL: Likely compensated congestive heart failure (CHF)
200 to 400 pg/mL: Likely moderate CHF
>400 pg/mL: Likely moderate to severe CHF
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Chippewa Falls​ ​Monday through Friday ​Less than 2 hours​ ​Fluorescence Immunoassay/Triage Meter Alere
​Weston
 ​Monday through Sunday​ ​Less than 2 hours​ ​​Fluorescence Immunoassay/Triage Meter Alere
​Eau Claire ​Monday through Sunday​ ​Less than 2 hours​ ​​two-step immunoenzymatic assay/Beckman access2/DXI
Park Falls​
 ​Monday through Sunday​ ​Less than 2 hours​ ​​two-step immunoenzymatic assay/Beckman access2/DXI
​Ladysmith Medical Center ​​Monday through Sunday ​Less than 2 hours​ ​​​​two-step immunoenzymatic assay/Beckman access2/DXI​
Marshfield​ Monday through Sunday​ Less than 2 hours​ two-step immunoenzymatic assay/​Beckman DXI 
Minocqua​ ​Monday through Sunday​ ​Less than 2 hours​ ​​​​two-step immunoenzymatic assay/Beckman access2/DXI
​Neillsville​Monday through Sunday​​Less than 2 hours​​Fluorescence Immunoassay/Triage Meter Alere
Rice Lake​​
​Monday through Sunday​
​​Less than 2 hours
​​​two-step immunoenzymatic assay/Beckman access2/DXI
Stevens Point​​Monday through Sunday​​Less than 2 hours​​​​​​​​two-step immunoenzymatic assay/Beckman access2/DXI​ 
​Wisconsin Rapids ​Monday through Sunday ​Less than 2 hours ​Fluorescence Immunoassay/Triage Meter Alere
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83880​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.