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24860 Heavy Metals Screen, with Reflex, 24 Hour, Urine (HMU24)

Heavy Metals Screen, with Reflex, 24 Hour, Urine (HMU24)
Test Code: HMETUSO
Synonyms/Keywords
Arsenic (As), As (Arsenic), Cadmium (Cd), Cd (Cadmium), Hg (Mercury), Lead (Pb), Mercury (Hg), Metals Screens, Pb (Lead), Toxicology Quantitative Screen, Metals
Test Components

Arsenic, Cadmium, Mercury, Lead

​If arsenic concentration is greater than or equal to 10 mcg/L, then speciation will be performed at an additional charge. 

Useful For

​Detecting arsenic, cadmium, mercury and lead exposure and toxicity using 24-hour urine specimen. 

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Urine​ ​Clean, plastic aliquot container with no metal cap or glued insert.  Plastic container, 10 mL urine tube (Supply T068) ​ ​10 mL ​3 mL ​
Collection Processing Instructions
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

1. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

2. Patient should not eat seafood for a 48-hour period prior to start of, or during, collection. 

Specimen Stability Information
Specimen Type Temperature​Time
​Urine ​ ​Refrigerated (preferred)​7 days
​Frozen ​7 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 

Interference

​Consumption of seafood before collection of a urine specimen for arsenic testing is likely to result in a report of an elevated concentration of arsenic found in the urine, which can be clinically misleading.

Collection of urine specimens through a catheter frequently results in elevated values because rubber contains trace amounts of cadmium that are extracted as urine passes through the catheter.

To avoid contamination by dust, specimen should be collected away from the site of suspected exposure.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​ ​1 to 3 days
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information

ARSENIC:

0-17 years: not established

> or =18 years: <35 mcg/24 hour

CADMIUM:

0-17 years: not established

> or =18 years: <0.7mcg/24 hour

MERCURY:

0-17 years: not established

> or =18 years: <2 mcg/24 hour

Toxic concentration: >50 mcg/24 hour

The concentration at which toxicity is expressed is widely variable between patients.

50 mcg/24 hour is the lowest concentration at which toxicity is usually apparent.

LEAD:

0-17 years: not established

> or =18 years: <2 mcg/24 hour

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82175 ​ ​1 ​Arsenic ​
​83825 ​ ​1 ​Mercury ​
​82300 ​ ​1 ​Cadmium ​
​83655 ​ ​1 ​Lead ​
​82175​​1​​if needed
Synonyms/Keywords
Arsenic (As), As (Arsenic), Cadmium (Cd), Cd (Cadmium), Hg (Mercury), Lead (Pb), Mercury (Hg), Metals Screens, Pb (Lead), Toxicology Quantitative Screen, Metals
Test Components

Arsenic, Cadmium, Mercury, Lead

​If arsenic concentration is greater than or equal to 10 mcg/L, then speciation will be performed at an additional charge. 

Ordering Applications
Ordering Application Description
​COM​Heavy Metals Screen w/Reflex, 24 Hr Ur (HMU24)
​Cerner​Heavy Metals Scree, with Reflex, 24 Hour, Urine (HMU24)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Urine​ ​Clean, plastic aliquot container with no metal cap or glued insert.  Plastic container, 10 mL urine tube (Supply T068) ​ ​10 mL ​3 mL ​
Collection Processing
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

1. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

2. Patient should not eat seafood for a 48-hour period prior to start of, or during, collection. 

Specimen Stability Information
Specimen Type Temperature​Time
​Urine ​ ​Refrigerated (preferred)​7 days
​Frozen ​7 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 

Interference

​Consumption of seafood before collection of a urine specimen for arsenic testing is likely to result in a report of an elevated concentration of arsenic found in the urine, which can be clinically misleading.

Collection of urine specimens through a catheter frequently results in elevated values because rubber contains trace amounts of cadmium that are extracted as urine passes through the catheter.

To avoid contamination by dust, specimen should be collected away from the site of suspected exposure.

Useful For

​Detecting arsenic, cadmium, mercury and lead exposure and toxicity using 24-hour urine specimen. 

Test Components

Arsenic, Cadmium, Mercury, Lead

​If arsenic concentration is greater than or equal to 10 mcg/L, then speciation will be performed at an additional charge. 

Reference Range Information

ARSENIC:

0-17 years: not established

> or =18 years: <35 mcg/24 hour

CADMIUM:

0-17 years: not established

> or =18 years: <0.7mcg/24 hour

MERCURY:

0-17 years: not established

> or =18 years: <2 mcg/24 hour

Toxic concentration: >50 mcg/24 hour

The concentration at which toxicity is expressed is widely variable between patients.

50 mcg/24 hour is the lowest concentration at which toxicity is usually apparent.

LEAD:

0-17 years: not established

> or =18 years: <2 mcg/24 hour

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​ ​1 to 3 days
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82175 ​ ​1 ​Arsenic ​
​83825 ​ ​1 ​Mercury ​
​82300 ​ ​1 ​Cadmium ​
​83655 ​ ​1 ​Lead ​
​82175​​1​​if needed
For most current information refer to the Marshfield Laboratory online reference manual.