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26488 Disaccharidase Activity Panel, Tissue (DSAC)

Disaccharidase Activity Panel, Tissue (DSAC)
Test Code: DSACSO
Synonyms/Keywords

​​​Disaccharidase Determination

Useful For

Evaluation of patients who present with signs or symptoms suggestive of disaccharidase disorders

This test is not intended for carrier detection.

GENETICS TEST INFORMATION: 

Diagnostic testing for patients with clinical signs and symptoms suspicious of a disaccharidase deficiency.

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​Tissue
Intestinal Biopsy
​Tissue Tube-DSAC (T993)
​​5 mg
​5 mg​
Collection Processing Instructions

​Place Specimen in tissue tube.

Specimen should not be placed on gauze, filter paper, or swabs/wooden sticks and should not have any saline, water, support, or embedding material added.​

Freeze immediately after collection and ship frozen.

Specimen Stability Information
Specimen TypeTemperatureTime
​Tissue​Frozen 
​28 days
Rejection Criteria
Specimens sent in formaldehyde, saline or any supportive media; gauze, filter paper, foil or swabs/wooden sticks
Interference

​This test will not distinguish between primary and secondary causes of disaccharidase deficiencies.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​3 to 5 days​Spectrophotometry
Reference Lab
Mayo Clinic Laboratories
Test Information
Disaccharidases in the small intestines are responsible for the breakdown of disaccharides (double sugars) into monosaccharides (simple sugars). Patients with a deficiency of 1 or more disaccharidase enzymes can experience intolerance to foods containing complex sugars resulting in a range of gastrointestinal symptoms including diarrhea or constipation, abdominal pain and cramping, gas, bloating, and nausea. In addition, patients may experience malnutrition, weight loss, or failure to thrive. Given the nonspecificity and frequency of abdominal symptoms, misdiagnosis or a diagnostic delay of disaccharide deficiencies may occur.

Primary and secondary causes of disaccharidase deficiencies exist, and age of onset may vary from birth through adulthood. Primary causes are rare and result from genetic alterations in a variety of genes. Secondary deficiencies typically result from small intestinal mucosal damage. Treatment of both primary and secondary disaccharidase deficiencies involves dietary management. While primary deficiencies require lifelong treatment, secondary disaccharidase deficiencies may require treatment only until the intestinal lining recovers.
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​

Lactase: > or =14.0 nmol/min/mg protein

Sucrase: > or =19.0 nmol/min/mg protein

Maltase: > or =70.0 nmol/min/mg protein

Palatinase: > or =6.0 nmol/min/mg protein

Glucoamylase: > or =8.0 nmol/min/mg protein

Interpretation

​Quantitative values of lactase, sucrase, maltase, palatinase, and glucoamylase are reported. Clinical interpretation of results is provided.

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​82657​​1​​
Synonyms/Keywords

​​​Disaccharidase Determination

Ordering Applications
Ordering ApplicationDescription
​Cerner​Disaccharidase Activity Panel (DSAC)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​Tissue
Intestinal Biopsy
​Tissue Tube-DSAC (T993)
​​5 mg
​5 mg​
Collection Processing

​Place Specimen in tissue tube.

Specimen should not be placed on gauze, filter paper, or swabs/wooden sticks and should not have any saline, water, support, or embedding material added.​

Freeze immediately after collection and ship frozen.

Specimen Stability Information
Specimen TypeTemperatureTime
​Tissue​Frozen 
​28 days
Rejection Criteria
Specimens sent in formaldehyde, saline or any supportive media; gauze, filter paper, foil or swabs/wooden sticks
Interference

​This test will not distinguish between primary and secondary causes of disaccharidase deficiencies.

Useful For

Evaluation of patients who present with signs or symptoms suggestive of disaccharidase disorders

This test is not intended for carrier detection.

GENETICS TEST INFORMATION: 

Diagnostic testing for patients with clinical signs and symptoms suspicious of a disaccharidase deficiency.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​

Lactase: > or =14.0 nmol/min/mg protein

Sucrase: > or =19.0 nmol/min/mg protein

Maltase: > or =70.0 nmol/min/mg protein

Palatinase: > or =6.0 nmol/min/mg protein

Glucoamylase: > or =8.0 nmol/min/mg protein

Interpretation

​Quantitative values of lactase, sucrase, maltase, palatinase, and glucoamylase are reported. Clinical interpretation of results is provided.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​3 to 5 days​Spectrophotometry
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​82657​​1​​
For most current information refer to the Marshfield Laboratory online reference manual.