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26656 Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid (ROC)

Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid (ROC)
Test Code: MISC
Synonyms/Keywords

Measles Virus

Rubeola Antibodies, IgG and IgM (Separate Determinations), Spinal Fluid​

Test Components

​​Rubeola (Measles) Ab, IgG

Rubeola (Measles) Ab, IgM

Useful For

​Diagnosing central nervous system rubeola (measles) virus infection and/or subacute sclerosing panencephalitis

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)

​CSF
​Sterile vial

​​​0.25 mL
​0.1 mL
​
Collection Processing Instructions

​Submit specimen from collection vial number 2 (preferred), 3, or 4.

Specimen Stability Information
Specimen TypeTemperatureTime

​
​CSF​
​

​Refrigerated (preferred)
​14 days
​Frozen
​14 days
Interference

​Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport Available
Methodology/Instrumentation

​Mayo Clinic
Laboratories
​Monday through Friday
​​​1 to 4 days
​Immunofluorescence Assay (IFA)
Reference Lab
Mayo Clinic Laboratories
Test Information

Measles is a serious and highly contagious disease that can be a leading cause of death where nutrition and sanitation are limited. Onset begins with cough, fever, and lymphadenopathy approximately 2 weeks after exposure. Diagnosis is usually made when the rash appears. Koplik spots may be seen earlier on the buccal mucosa. Complications of measles may develop in children who appear to have normal immune functions.

Persistent infection of the central nervous system with measles virus is recognized to cause the disease subacute sclerosing panencephalitis (SSPE). SSPE is a rare, late complication of measles with an incidence of approximately 1 per 100,000 cases. SSPE is a progressive, usually fatal disease that occurs most often in children between the ages of 5 and 14 years. The onset is insidious and progressive. The incubation period from acute measles to onset of neurological symptoms varies from several months to many years. One of the most useful diagnostic tests involves the measurement of measles-specific antibodies in the cerebrospinal fluid (CSF) of patients with SSPE. Levels of antibody are significantly elevated in the CSF of SSPE patients compared to those without the disease.​

Reference Range Information

IgG: <1:5

IgM: <1:10

Reference values apply to all ages.

Interpretation

Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

 Patients with subacute sclerosing panencephalitis have serum antibody titers that are 10 to 100 times higher than those seen in late convalescent-phase sera. More importantly, there is pronounced local production of oligoclonal measles virus antibodies in the central nervous system.

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments

​86765
​​​2
​​
Synonyms/Keywords

Measles Virus

Rubeola Antibodies, IgG and IgM (Separate Determinations), Spinal Fluid​

Test Components

​​Rubeola (Measles) Ab, IgG

Rubeola (Measles) Ab, IgM

Ordering Applications
Ordering ApplicationDescription

​Cerner
​MISC
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)

​CSF
​Sterile vial

​​​0.25 mL
​0.1 mL
​
Collection Processing

​Submit specimen from collection vial number 2 (preferred), 3, or 4.

Specimen Stability Information
Specimen TypeTemperatureTime

​
​CSF​
​

​Refrigerated (preferred)
​14 days
​Frozen
​14 days
Interference

​Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

Useful For

​Diagnosing central nervous system rubeola (measles) virus infection and/or subacute sclerosing panencephalitis

Test Components

​​Rubeola (Measles) Ab, IgG

Rubeola (Measles) Ab, IgM

Reference Range Information

IgG: <1:5

IgM: <1:10

Reference values apply to all ages.

Interpretation

Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

 Patients with subacute sclerosing panencephalitis have serum antibody titers that are 10 to 100 times higher than those seen in late convalescent-phase sera. More importantly, there is pronounced local production of oligoclonal measles virus antibodies in the central nervous system.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport Available
Methodology/Instrumentation

​Mayo Clinic
Laboratories
​Monday through Friday
​​​1 to 4 days
​Immunofluorescence Assay (IFA)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments

​86765
​​​2
​​
For most current information refer to the Marshfield Laboratory online reference manual.