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22204 Haptoglobin

Haptoglobin
Test Code: HAPTO
Synonyms/Keywords
Haptoglobin​
Useful For
This test is useful for monitoring haptoglobin levels in serum.

The haptoglobin system is an important mechanism for iron conservation. Decreased values are seen with any hemolytic disorder or process that damages red blood cells. Increased inflammatory conditions, some malignancies, tissue damage, corticosteroid and estrogen therapy. ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL 0.4 mL 0.3 mL
Collection Processing Instructions
 ​Separate serum from cells within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen 3 months
Rejection Criteria
Hemolysis
Plasma samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
Reference Range Information
Performing Location Reference Range
Marshfield​ 50-220 mg/dL​
Interpretation
Haptoglobin is an alpha-2 globulin that acts as a scavenger of free hemoglobin by formation of a complex.  The hemoglobin/haptoglobin complex is large enough to prevent loss by filtration in the kidneys.  The complex is then catabolized the the Reticulo Endothial System and the iron is recycled.  This is an important mechanism for iron conservation.  Decreased values are seen with any hemolytic disorder or process that damages red blood cells.  Haptoglobin is also an acute phase reactant, and its synthesis is stimulated by inflammatory conditions (leading to increase levels).  Increased levels are also seen in certain malignancies, tissue damage with burns, and with corticosteroid and estrogen therapy.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83010​ ​ ​ ​ ​
Synonyms/Keywords
Haptoglobin​
Ordering Applications
Ordering Application Description
​Cerner ​Haptoglobin
​COM ​Haptoglobin
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL 0.4 mL 0.3 mL
Collection Processing
 ​Separate serum from cells within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen 3 months
Rejection Criteria
Hemolysis
Plasma samples​
Useful For
This test is useful for monitoring haptoglobin levels in serum.

The haptoglobin system is an important mechanism for iron conservation. Decreased values are seen with any hemolytic disorder or process that damages red blood cells. Increased inflammatory conditions, some malignancies, tissue damage, corticosteroid and estrogen therapy. ​
Reference Range Information
Performing Location Reference Range
Marshfield​ 50-220 mg/dL​
Interpretation
Haptoglobin is an alpha-2 globulin that acts as a scavenger of free hemoglobin by formation of a complex.  The hemoglobin/haptoglobin complex is large enough to prevent loss by filtration in the kidneys.  The complex is then catabolized the the Reticulo Endothial System and the iron is recycled.  This is an important mechanism for iron conservation.  Decreased values are seen with any hemolytic disorder or process that damages red blood cells.  Haptoglobin is also an acute phase reactant, and its synthesis is stimulated by inflammatory conditions (leading to increase levels).  Increased levels are also seen in certain malignancies, tissue damage with burns, and with corticosteroid and estrogen therapy.​
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83010​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.