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22418 Ceruloplasmin

Ceruloplasmin
Test Code: CERULO
Synonyms/Keywords
​Copper Oxidase
Useful For
​This test is useful for monitoring ceruloplasmin levels in blood. Decreased levels are primarily of interest in the diagnosis of Wilson's disease. Decreased levels are also seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired. Ceruloplasmin, and acute phase reactant, is increased in inflammatory disorders when estrogen levels are high, with malignant tumors, and acute leukemia.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL​ 0.4 mL​ 0.3 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.​

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen 3 months​
Rejection Criteria
Plasma samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday- Friday
 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
Test Information
​ Oral contraceptives or estrogen will increase ceruloplasmin levels.
Reference Range Information
Performing Location Reference Range
Marshfield​ 20-60 mg/dL​
Interpretation
​Decreased ceruloplasmin levels may be seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired.  Decreased levels are primarily of interest in the diagnosis of Wilson's Disease, also known as hepatolenticular degeration.  This involves a defect in ceruloplasmin synthesis and results in excessive accumulation of copper in various body tissues - liver, cornea and brain tissue.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82390 ​ ​ ​ ​
Synonyms/Keywords
​Copper Oxidase
Ordering Applications
Ordering Application Description
​Cerner ​Ceruloplasmin
​COM ​Ceruloplasmin
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL​ 0.4 mL​ 0.3 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.​

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen 3 months​
Rejection Criteria
Plasma samples
Useful For
​This test is useful for monitoring ceruloplasmin levels in blood. Decreased levels are primarily of interest in the diagnosis of Wilson's disease. Decreased levels are also seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired. Ceruloplasmin, and acute phase reactant, is increased in inflammatory disorders when estrogen levels are high, with malignant tumors, and acute leukemia.
Reference Range Information
Performing Location Reference Range
Marshfield​ 20-60 mg/dL​
Interpretation
​Decreased ceruloplasmin levels may be seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired.  Decreased levels are primarily of interest in the diagnosis of Wilson's Disease, also known as hepatolenticular degeration.  This involves a defect in ceruloplasmin synthesis and results in excessive accumulation of copper in various body tissues - liver, cornea and brain tissue.
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday- Friday
 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82390 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.