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22555 Dehydroepiandrosterone Sulfate (DHEA-SO4)

Dehydroepiandrosterone Sulfate (DHEA-SO4)
Test Code: DHEASO4
Synonyms/Keywords
​DHEA-SO4​
Useful For
​This test is useful in the diagnosis of congenital adrenal hyperplasia and adrenal carcinoma and determining the cause of hirsutism, virilization, and polycystic ovary disease. Sometimes, this test is ordered in conjunction with plasma DHEA (Test # 81405 sent to Mayo Medical Labs).​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.3 mL​
Collection Processing Instructions
Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in gel barrier tubes must be removed from the primary tube prior to transporting to Marshfield. Do not send the primary collection tube. DHEASO4 is not the same test as DHEA (See Test Information).​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated ​ 2 days​
Frozen​ 2 months​
Rejection Criteria
Grosssly lipemic
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ DPC Immulite Chemiluminescent EIA  ​
Test Information
DHEA-SO4 has little androgenic activity but is the precursor for peripheral conversion to the active androgens following the metabolic pathway of DHEA, androstenedione, testosterone, and dihydrotestosterone, with increasing androgenic potency in that order. Measurement of DHEA-SO4 is to determine the adrenal source of androgen. Excessive adrenal secretion of the androgen precursor has a noticeable clinical consequence. Clinical manifestations include hirsutism, virilization, and polycystic ovary disease.

The drug asfotase alfa (STRENSIQ), a recombinant form of alkaline phosphatase, is expected to interfere with in vitro diagnostic assays utilizing an alkaline phosphatase detection system. Test samples from patients taking asfotase alfa with a non-alkaline phosphatase methodology.​ 

Reference Range Information
Performing Location Reference Range
Marshfield​
                   Male (ug/dL)     Female (ug/dL)
  0-1 month:        9-316                15-261
  1-6 months:       3-58                   0-74
  7-36 months:     0-26                   0-26
  4-6 years:          0-34                   0-34
  7-9 years:          0-74                   0-74
10-12 years:        3-137                 3-137
13-18 years:        3-237                 3-237
19-29 years:      140-640              65-380
30-49 years:       95-530               32-270
 >=50 years:       40-310              <30-200
 
  Pediatric reference ranges taken from:
  Soldin, S.J. et.al., "Pediatric Reference
  Ranges for DHEA Sulfate"  ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82627 ​ ​ ​ ​
Synonyms/Keywords
​DHEA-SO4​
Ordering Applications
Ordering Application Description

​Cerner
​Dehydroepiandrosterone Sulfate (DHEA-SO4)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.3 mL​
Collection Processing
Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in gel barrier tubes must be removed from the primary tube prior to transporting to Marshfield. Do not send the primary collection tube. DHEASO4 is not the same test as DHEA (See Test Information).​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated ​ 2 days​
Frozen​ 2 months​
Rejection Criteria
Grosssly lipemic
Useful For
​This test is useful in the diagnosis of congenital adrenal hyperplasia and adrenal carcinoma and determining the cause of hirsutism, virilization, and polycystic ovary disease. Sometimes, this test is ordered in conjunction with plasma DHEA (Test # 81405 sent to Mayo Medical Labs).​
Reference Range Information
Performing Location Reference Range
Marshfield​
                   Male (ug/dL)     Female (ug/dL)
  0-1 month:        9-316                15-261
  1-6 months:       3-58                   0-74
  7-36 months:     0-26                   0-26
  4-6 years:          0-34                   0-34
  7-9 years:          0-74                   0-74
10-12 years:        3-137                 3-137
13-18 years:        3-237                 3-237
19-29 years:      140-640              65-380
30-49 years:       95-530               32-270
 >=50 years:       40-310              <30-200
 
  Pediatric reference ranges taken from:
  Soldin, S.J. et.al., "Pediatric Reference
  Ranges for DHEA Sulfate"  ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ DPC Immulite Chemiluminescent EIA  ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82627 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.