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22615 Immunoglobulin D (IgD), Serum (IGD)

Immunoglobulin D (IgD), Serum (IGD)
Test Code: IGDSO
Synonyms/Keywords
IgD (Immunoglobulin D), Immune Competence
Useful For
​Providing important information on the humoral immune status
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Collection Processing Instructions

​Fasting preferred but not required

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 28 days​
Ambient ​ 21 days​
Frozen ​ 28 days​
Rejection Criteria
Gross lipemia
Interference

​An elevated IgD cannot be taken as evidence for a monoclonal IgD protein. MPSS / Monoclonal Protein Studies, Serum should be performed to distinguish between a polyclonal and monoclonal IgD.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​
1-3 days​
Turbidimetry
Reference Lab
Mayo Clinic Laboratories
Test Information

​Antibodies or immunoglobulins (Ig) are formed by plasma cells as a humoral immune response to antigens. The first antibodies formed after antigen stimulation are of the IgM class, followed later by IgG and also IgA antibodies. IgD normally occurs in serum in trace amounts.

Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic diseases (chronic hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases, as well as in the cord blood of neonates with intrauterine and perinatal infections. Increases in serum immunoglobulin concentration are seen in monoclonal gammopathies such as multiple myeloma, Waldenstrom macroglobulinemia, primary amyloidosis, and monoclonal gammopathy of undetermined significance.

Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies including advanced monoclonal gammopathies, lymphatic leukemia, and advanced malignant tumors.

Changes in IgD concentration are used as a marker of changes in the size of the clone of monoclonal IgD plasma cells.

Reference Range Information
< or = 10 mg/dL
Interpretation
​The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.
 
Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.
 
A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable M-peak on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82784 ​ ​ ​ ​
Synonyms/Keywords
IgD (Immunoglobulin D), Immune Competence
Ordering Applications
Ordering Application Description
​Centricity ​IgD Quantitation
​Cerner IgD​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Collection Processing

​Fasting preferred but not required

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 28 days​
Ambient ​ 21 days​
Frozen ​ 28 days​
Rejection Criteria
Gross lipemia
Interference

​An elevated IgD cannot be taken as evidence for a monoclonal IgD protein. MPSS / Monoclonal Protein Studies, Serum should be performed to distinguish between a polyclonal and monoclonal IgD.

Useful For
​Providing important information on the humoral immune status
Reference Range Information
< or = 10 mg/dL
Interpretation
​The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.
 
Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.
 
A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable M-peak on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​
1-3 days​
Turbidimetry
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82784 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.