Hepatitis B is a viral illness that is transmitted through blood and other body fluids. Both acute and chronic stages occur, with the frequency of progression to chronicity declining with age at time of infection. Chronic hepatitis B often leads to cirrhosis and hepatocellular carcinoma. Hepatitis B is a vaccine-preventable disease.
Limitations • The results determined by different assays from different manufacturers can vary due to differences in assay specificities and cannot be used interchangeably. • The performance of the assay has not been established with cord blood, neonatal specimens, infants, children, or adolescent patients, immunocompromised, immunosuppressed, cadaver specimens, heat-inactivated specimens, or body fluids. • A reactive Anti-Hepatitis B core Total result does not exclude co-infection by another hepatitis virus.
The presence of hepatitis B core total antibody is consistent with both acute and chronic hepatitis B. The HEPATITIS B CORE ANTIBODY, IgM (test code ABC-M) may be used to resolve these two phases.
A result of a single hepatitis B lab study should be interpreted with caution.