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22841 Lupus Anticoagulant Panel

Lupus Anticoagulant Panel
Test Code: LAPAN
Synonyms/Keywords
Lupus Inhibitor Work-up, Lupus Inhibitor Panel​
Test Components
Dilute Russell Viper Venom Time (DRVVT), Silica Clotting Time (SCT)
Useful For
​Recommended for the evaluation of patients with thrombosis and/or prolonged phospholipid-dependent clotting assays (ex: PT and APTT).  This panel is not recommended to aid in the diagnosis of Systemic Lupus Erythematosis (SLE), see ANA EIA (ANA HEp-2 Serum Screen).
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ One 1.0 mL aliquot​ 0.75 mL​ 0.5 mL ​
Collection Processing Instructions
One 1.0 mL citrated Blue Top Tube (BTT) plasma aliquot.
If other coagulation tests are ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tubes must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for:  Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​ ​ ​PlasmaRoom Temp​​4 hours
​Refrigerated​4 hours
​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Performing Laboratory Information
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday, Wednesday, Friday​Less than 2 hours Optical clot detection/ACL TOP 550
Test Information
The detection of a lupus anticoagulant, a heterogeneous group of antibodies, is enhanced by performing two or more screening tests.  Therefore, the LUPUS ANTICOAGULANT PANEL includes both a DRVVT and SCT.  If results of either or both tests are positive for LA, a lupus anticoagulant is present.  Platelet poor plasma plasma platelet count must be less than 10,000/uL.  Test results may be falsely negative due to the presence of excess platelets in the plasma.​
 
Requested panel includes Lupus anticoagulant testing (DRVVT and SCT), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, or warfarin.  For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​​85613​​​Dilute Russell Viper Venom Time​​Optical Clot Detection
​85732 ​ ​ Silica Clotting Time​ ​​Optical Clot Detection
Synonyms/Keywords
Lupus Inhibitor Work-up, Lupus Inhibitor Panel​
Test Components
Dilute Russell Viper Venom Time (DRVVT), Silica Clotting Time (SCT)
Ordering Applications
Ordering Application Description
​Centricity ​Lupus Anticoag Panel
​Cerner ​Lupus Anticoagulant Panel
​COM ​Lupus Anticoagulant Panel
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ One 1.0 mL aliquot​ 0.75 mL​ 0.5 mL ​
Collection Processing
One 1.0 mL citrated Blue Top Tube (BTT) plasma aliquot.
If other coagulation tests are ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tubes must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for:  Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​ ​ ​PlasmaRoom Temp​​4 hours
​Refrigerated​4 hours
​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Useful For
​Recommended for the evaluation of patients with thrombosis and/or prolonged phospholipid-dependent clotting assays (ex: PT and APTT).  This panel is not recommended to aid in the diagnosis of Systemic Lupus Erythematosis (SLE), see ANA EIA (ANA HEp-2 Serum Screen).
Test Components
Dilute Russell Viper Venom Time (DRVVT), Silica Clotting Time (SCT)
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
For more information visit:
Performing Laboratory Information
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday, Wednesday, Friday​Less than 2 hours Optical clot detection/ACL TOP 550
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​​85613​​​Dilute Russell Viper Venom Time​​Optical Clot Detection
​85732 ​ ​ Silica Clotting Time​ ​​Optical Clot Detection
For most current information refer to the Marshfield Laboratory online reference manual.