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22872 Metanephrines, Urine 24 Hour (24 MET)

Metanephrines, Urine 24 Hour (24 MET)
Test Code: MET
Synonyms/Keywords
​24 MET, Metanephrine, Normetanephrine; Metanephrine Fractionation​
Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ 24 hr urine jug with 7 g sulfamic acid preservative​
24 hr urine jug with 20 mL 6N HCl ​
 
 10 mL aliquot from a well mixed 24 hr urine​ 5 mL aliquot​ 5 mL aliquot​
Collection Processing Instructions
Indicate collection dates and times.  Total volume must be measured, recorded and included with the test request.  
Urine must be preserved for the entire collection. Add acid preservative to collection jug prior to start of collection.
If urine was not collected for a 22-26 hour duration, sample will be rejected and ordering provider notified. The appropriate test to order for samples collected of duration less than 22 hours is "Metanephrine Fractionation, Urine Random" (U MET).​​​​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week​
​Frozen​1 week
Rejection Criteria
Specimens that are improperly preserved.
Specimens that are unpreserved.
​Urine collected for durations other than 22-26 hours
Interference

​Patients should be off Buspirone (“Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.

Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Marshfield​

Monday, Wednesday, Friday​

Samples must be in the performing department by 8am on the day of testing for results the same day

6-8 hours​

Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System

Test Information
Patient results determined by other methods may not be comparable.

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 50-840 ug/24 hr

Metanephrine: 0-370 ug/24 hr

Reference ranges are based on hypertensive population results​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Synonyms/Keywords
​24 MET, Metanephrine, Normetanephrine; Metanephrine Fractionation​
Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Ordering Applications
Ordering Application Description
​Cerner
 Metanephrines, Urine 24 Hour

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ 24 hr urine jug with 7 g sulfamic acid preservative​
24 hr urine jug with 20 mL 6N HCl ​
 
 10 mL aliquot from a well mixed 24 hr urine​ 5 mL aliquot​ 5 mL aliquot​
Collection Processing
Indicate collection dates and times.  Total volume must be measured, recorded and included with the test request.  
Urine must be preserved for the entire collection. Add acid preservative to collection jug prior to start of collection.
If urine was not collected for a 22-26 hour duration, sample will be rejected and ordering provider notified. The appropriate test to order for samples collected of duration less than 22 hours is "Metanephrine Fractionation, Urine Random" (U MET).​​​​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week​
​Frozen​1 week
Rejection Criteria
Specimens that are improperly preserved.
Specimens that are unpreserved.
​Urine collected for durations other than 22-26 hours
Interference

​Patients should be off Buspirone (“Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.

Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.

Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors

Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 50-840 ug/24 hr

Metanephrine: 0-370 ug/24 hr

Reference ranges are based on hypertensive population results​

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Marshfield​

Monday, Wednesday, Friday​

Samples must be in the performing department by 8am on the day of testing for results the same day

6-8 hours​

Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System

For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.