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22873 Metanephrine Fractionation, Urine Random (U MET)

Metanephrine Fractionation, Urine Random (U MET)
Test Code: MET-RND
Synonyms/Keywords
U MET, Metanephrine, Normetanephrine; Metanephrines/Creatinine Ratio​
Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage cup with 0.1 g sulfamic acid
50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5​
 10 mL​ 5 mL urine​ 5 mL urine​
Collection Processing Instructions
Urine must be preserved immediately at the time of collection.
Specimen Stability Information

Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week
​Frozen
​1 week
Rejection Criteria
​Specimens that are unpreserved.
Interference

Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.

​Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.

Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​

Monday, Wednesday, Friday​

Samples must be in the performing department by 8am on the day of testing for results the same day
6-8 hours​Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System
Test Information
Patient results determined by other methods may not be comparable.

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 69 – 750 ug/g creatinine

Metanephrine: 27 – 270 ug/g creatinine ​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Synonyms/Keywords
U MET, Metanephrine, Normetanephrine; Metanephrines/Creatinine Ratio​
Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Ordering Applications
Ordering Application Description
​Cerner ​Metanephrine Fractionated, Urine Random

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage cup with 0.1 g sulfamic acid
50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5​
 10 mL​ 5 mL urine​ 5 mL urine​
Collection Processing
Urine must be preserved immediately at the time of collection.
Specimen Stability Information

Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week
​Frozen
​1 week
Rejection Criteria
​Specimens that are unpreserved.
Interference

Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.

​Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.

Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 69 – 750 ug/g creatinine

Metanephrine: 27 – 270 ug/g creatinine ​

For more information visit:
Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​

Monday, Wednesday, Friday​

Samples must be in the performing department by 8am on the day of testing for results the same day
6-8 hours​Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.