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22881 Methylmalonic Acid

Methylmalonic Acid
Test Code: MMA
Synonyms/Keywords
Methylmalonic acid quantitative - serum, MMA​
Useful For
Methylmalonic acid (MMA) is a metabolite that accumulates when vitamin B12 (cobalamin) is unavailable as a cofactor for converting methylmalonyl-CoA to succinyl-CoA.  Measurement of MMA is helpful as a confirmatory test for patients with borderline low serum vitamin B12 levels.  A normal MMA result rules out B12 deficiency states.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube
(RTT)​
Serum Separator Tube
(SST)​
 250 uL 200 uL
Collection Processing Instructions

Separate serum/plasma from cells within 2 hours of collection.​



 

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 1 week​
Freeze​ 1 year​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Thursday
 6-8 hours​ UPLC MS/MS (Waters TQ-XS LC Tandem Mass Spectrometry system)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Reference Range Information
Performing Location Reference Range
Marshfield​ < or = 0.40 umol/L​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83921​ ​ ​ ​ ​
Synonyms/Keywords
Methylmalonic acid quantitative - serum, MMA​
Ordering Applications
Ordering Application Description
​COM ​Methylmalonic AC(MMA),Qnt.Serum
​Cerner ​Methylmalonic Acid Level
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube
(RTT)​
Serum Separator Tube
(SST)​
 250 uL 200 uL
Collection Processing

Separate serum/plasma from cells within 2 hours of collection.​



 

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 1 week​
Freeze​ 1 year​
Useful For
Methylmalonic acid (MMA) is a metabolite that accumulates when vitamin B12 (cobalamin) is unavailable as a cofactor for converting methylmalonyl-CoA to succinyl-CoA.  Measurement of MMA is helpful as a confirmatory test for patients with borderline low serum vitamin B12 levels.  A normal MMA result rules out B12 deficiency states.​
Reference Range Information
Performing Location Reference Range
Marshfield​ < or = 0.40 umol/L​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Thursday
 6-8 hours​ UPLC MS/MS (Waters TQ-XS LC Tandem Mass Spectrometry system)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83921​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.