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22997 Immunoglobulin G (IgG)

Immunoglobulin G (IgG)
Test Code: IGG
Synonyms/Keywords
​Immunoglobulin G - quantitative; IgG
Useful For
​Quantitative immunoglobulins are useful for detecting or monitoring of monoclonal gammopathies and immune deficiencies.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST) 0.5 mL 0.4 mL 0.3 mL
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate 7 days​
Frozen​​ 3 months​
Rejection Criteria
Plasma samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
Test Information
​Immunoglobulins can also be ordered together as GAM (for IgG, IgA, IgM).
Reference Range Information
Performing Location Reference Range
Marshfield​ See table ​Immunoglobulin Reference Ranges
Interpretation
Quantitative immunoglobulins are useful for detecting or monitoring of monoclonal gammopathies and immune deficiencies. Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intra uterine and perinatal infections. Elevations of IgG, IgA, or IgM may occur in monoclonal gammopathies such as multiple myeloma (IgG, IgA), macroglobulinemia (IgM), primary systemic amyloidosis, monoclonal gammopathy of undetermined significance (MGUS), and related disorders.
 
Decreased levels are found in patients with primary or secondary immune deficiencies.
 
Immunoglobulin quantitation is used to monitor the size of a monoclonal protein that is contained in a background of polyclonal immunoglobulins; however, changes in the immunoglobulin quantitation may reflect changes in the background immunoglobulins.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​ ​ ​ ​
Synonyms/Keywords
​Immunoglobulin G - quantitative; IgG
Ordering Applications
Ordering Application Description
​Cerner ​Immunoglobulin G (IgG)
​Clinical Order Manager ​Prot.-Immunoglobulin IgG only
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST) 0.5 mL 0.4 mL 0.3 mL
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate 7 days​
Frozen​​ 3 months​
Rejection Criteria
Plasma samples
Useful For
​Quantitative immunoglobulins are useful for detecting or monitoring of monoclonal gammopathies and immune deficiencies.
Reference Range Information
Performing Location Reference Range
Marshfield​ See table ​Immunoglobulin Reference Ranges
Interpretation
Quantitative immunoglobulins are useful for detecting or monitoring of monoclonal gammopathies and immune deficiencies. Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intra uterine and perinatal infections. Elevations of IgG, IgA, or IgM may occur in monoclonal gammopathies such as multiple myeloma (IgG, IgA), macroglobulinemia (IgM), primary systemic amyloidosis, monoclonal gammopathy of undetermined significance (MGUS), and related disorders.
 
Decreased levels are found in patients with primary or secondary immune deficiencies.
 
Immunoglobulin quantitation is used to monitor the size of a monoclonal protein that is contained in a background of polyclonal immunoglobulins; however, changes in the immunoglobulin quantitation may reflect changes in the background immunoglobulins.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82784​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.