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24779 Hydrocodone & Metabolites, Free S (45004)

Hydrocodone & Metabolites, Free S (45004)
Test Code: HYDROSO
Synonyms/Keywords
Vicodin®, Hycodan®, Lortab®, Hysingla®, Zohydro®
Test Components

​Hydrocodone, Hydromophone, Dihydrocodeine

Useful For

​Therapeutic Drug Management

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​3 mL ​0.6 mL ​
​Plasma ​Lithium-heparin Green Top Tube or Sodium-heparin Green Top Tube (GTT) ​ 3 mL​ ​0.6 mL ​
Collection Processing Instructions

Trough levels are most reproducible

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​ Ambient ​ ​3 days
Specimen may also be refrigerated or frozen for longer storage.​
Rejection Criteria

​Gel-barrier tubes are not recommended

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ Performed daily​ 5 days​
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS-MS)​
Reference Lab
Medtox Laboratories
Reference Range Information
Performing Location Reference Range
Medtox Laboratories​
Hydrocodone: 10-100 ng/mL
Hydromorphone: 1-30 ng/mL
Dihydrocodeine: Not established
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80361 ​ ​ ​ ​
Synonyms/Keywords
Vicodin®, Hycodan®, Lortab®, Hysingla®, Zohydro®
Test Components

​Hydrocodone, Hydromophone, Dihydrocodeine

Ordering Applications
Ordering Application Description
​Centricity ​Hydrocodone, Serum (166)
​Cerner ​Hydrocodone, Serum (166)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​3 mL ​0.6 mL ​
​Plasma ​Lithium-heparin Green Top Tube or Sodium-heparin Green Top Tube (GTT) ​ 3 mL​ ​0.6 mL ​
Collection Processing

Trough levels are most reproducible

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​ Ambient ​ ​3 days
Specimen may also be refrigerated or frozen for longer storage.​
Rejection Criteria

​Gel-barrier tubes are not recommended

Useful For

​Therapeutic Drug Management

Test Components

​Hydrocodone, Hydromophone, Dihydrocodeine

Reference Range Information
Performing Location Reference Range
Medtox Laboratories​
Hydrocodone: 10-100 ng/mL
Hydromorphone: 1-30 ng/mL
Dihydrocodeine: Not established
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ Performed daily​ 5 days​
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS-MS)​
Reference Lab
Medtox Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80361 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.