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24816 Pregabalin (PGN)

Pregabalin (PGN)
Test Code: PGABSO
Synonyms/Keywords
Lyrica®​
Useful For
​Monitoring serum Lyrica®​ (pregabalin) concentrations, assessing compliance, and adjusting dosage in patients
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 1 mL 0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ Refrigerate (preferred) ​ 28 days
Ambient ​28 days
​Frozen ​28 days
Rejection Criteria

Serum Separator Tubes

Interference

​This test cannot be performed on whole blood.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available
 Methodology/Instrumentation
Mayo Clinic Laboratories​ Tuesday 2-7 days
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Test Information

​Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures in patients and is a more potent successor to gabapentin. Pregabalin is commonly used for neuropathic pain and fibromyalgia. This test can be used by healthcare providers to assess compliance and may be clinically useful in patients with kidney failure who generally require lower dosages. Therapeutic and toxic ranges are not well defined. Therapeutic concentrations are reported to be from 2 to 5 mcg/mL, while toxicity may occur at concentrations above 10 mcg/mL.​

Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​
2.0-5.0 mcg/mL
Interpretation

The serum concentration should be interpreted in the context of the patient's clinical response and other clinical tests. This may provide useful information in patients showing poor response, noncompliance, or adverse effects. Toxicity can occur with concentrations greater or equal to 10 mcg/mL.​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80299​
 ​ ​ ​ ​
Synonyms/Keywords
Lyrica®​
Ordering Applications
Ordering Application Description
​COM
 ​Pregabalin (PGN)
​Cerner ​Pregabalin (PGN​)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 1 mL 0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ Refrigerate (preferred) ​ 28 days
Ambient ​28 days
​Frozen ​28 days
Rejection Criteria

Serum Separator Tubes

Interference

​This test cannot be performed on whole blood.

Useful For
​Monitoring serum Lyrica®​ (pregabalin) concentrations, assessing compliance, and adjusting dosage in patients
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​
2.0-5.0 mcg/mL
Interpretation

The serum concentration should be interpreted in the context of the patient's clinical response and other clinical tests. This may provide useful information in patients showing poor response, noncompliance, or adverse effects. Toxicity can occur with concentrations greater or equal to 10 mcg/mL.​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available
 Methodology/Instrumentation
Mayo Clinic Laboratories​ Tuesday 2-7 days
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80299​
 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.