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24878 Serotonin Release Assay, Unfract Heparin (5508)

Serotonin Release Assay, Unfract Heparin (5508)
Test Code: SERRASO
Synonyms/Keywords
​ SRA-UFH, SRA-unfractionated heparin, SRA-Porcine Heparin, Serotonin Release Assay, Heparin-Induced Thrombocytopenia-SRA
Useful For
This test is designed to detect heparin-dependent platelet antibodies in the serum from patients suspected of having Heparin-Induced Thrombocytopenia (HIT).
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum (preferred)  or  Citrated Plasma (acceptable) Red Top Tube (RTT) ​​Citrated Blue Top Tube (BTT) ​5 mL ​1 mL ​1 mL
Collection Processing Instructions

This is a confirmatory test for heparin-induced thrombocytopenia (HIT). It is not offered as a stand-alone test, but rather is a reflex test for all positive platelet factor-4 (PF4) tests: coded as HITAB.  HITAB has excellent sensiti​vity and a negative test largely rules out HIT.  Repeat HITAB in a few days may be indicated in situations with a very compel​ling clinical picture for HIT.  Please refer questions to Dr. Gene Shaw (hematopathologist) or Jill Brantner (technical specialist in Hematology).​​

Sample should be spun down and taken off the red cells.  Sample must be received within 7 days of draw date.  Older samples are acceptable if they have been frozen. Submit refrigerated.  If already frozen, send on dry ice.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Citrated Plasma ​ ​ ​Refrigerated ​< 7 days
​Frozen @ -20°C    14 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Versiti Monday through Friday​ ​1-3 days ​Serotonin Release Assay (SRA)
Reference Lab
Versiti/Blood Center of Wisconsin
Test Information
Test includes heparin dependent platelet antibody serotonin release assay for unfractionated heparin. This test is used for the detection of heparin-dependent antibodies in heparin induced thrombocytopenia (HIT). Because of its high specificity, the SRA is often useful for confirmation of weak or 'inconclusive' results obtained with the highly sensitive PF4/ELISA. ​
Reference Range Information
An interpretive report
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86022​
 ​ ​ ​ ​
Synonyms/Keywords
​ SRA-UFH, SRA-unfractionated heparin, SRA-Porcine Heparin, Serotonin Release Assay, Heparin-Induced Thrombocytopenia-SRA
Ordering Applications
Ordering Application Description
​Cerner Serotonin Release Assay, Unfract Heparin (5508)​
​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum (preferred)  or  Citrated Plasma (acceptable) Red Top Tube (RTT) ​​Citrated Blue Top Tube (BTT) ​5 mL ​1 mL ​1 mL
Collection Processing

This is a confirmatory test for heparin-induced thrombocytopenia (HIT). It is not offered as a stand-alone test, but rather is a reflex test for all positive platelet factor-4 (PF4) tests: coded as HITAB.  HITAB has excellent sensiti​vity and a negative test largely rules out HIT.  Repeat HITAB in a few days may be indicated in situations with a very compel​ling clinical picture for HIT.  Please refer questions to Dr. Gene Shaw (hematopathologist) or Jill Brantner (technical specialist in Hematology).​​

Sample should be spun down and taken off the red cells.  Sample must be received within 7 days of draw date.  Older samples are acceptable if they have been frozen. Submit refrigerated.  If already frozen, send on dry ice.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Citrated Plasma ​ ​ ​Refrigerated ​< 7 days
​Frozen @ -20°C    14 days​
Useful For
This test is designed to detect heparin-dependent platelet antibodies in the serum from patients suspected of having Heparin-Induced Thrombocytopenia (HIT).
Reference Range Information
An interpretive report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Versiti Monday through Friday​ ​1-3 days ​Serotonin Release Assay (SRA)
Reference Lab
Versiti/Blood Center of Wisconsin
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86022​
 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.