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25075 NPM1 Mutation with CEBPA Analysis if Needed (4637)

NPM1 Mutation with CEBPA Analysis if Needed (4637)
Test Code: NPMCBSO
Synonyms/Keywords
​Ref Lab Code: 4637
Useful For

Useful for risk stratification in patients with cytogenetically normal Acute Myeloid Leukemia (AML).

Evaluation for familial AML.​

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Bone marrow ​EDTA Lavender Top Tube (LTT) ​ ​5 mL ​2 mL ​
​Whole blood EDTA Lavender Top Tube (LTT)​ ​ 5 mL​ ​2 mL ​
Collection Processing Instructions
​Submit sample at room temperature.
Specimen Stability Information
Specimen Type Temperature Time
​Bone marrow OR ​Whole blood ​Room temperature ​ ​7 days ​
Rejection Criteria
Samples not submitted in EDTA
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Blood Center of Wisconsin​ Monday through Friday​

​NPM1: 3-6 days

CEBPA Reflex: 10-14 days

 PCR​
Reference Lab
Versiti/Blood Center of Wisconsin
Test Information
This test will reflex to CEBPA mutations (at an additional charge) if the NPM1 is negative.
Reference Range Information
Interpretive report
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
81310​ ​ ​ NPM1 Mutation​ ​
81218​ ​ ​ CEBPA Analysis (if needed)​ ​
Synonyms/Keywords
​Ref Lab Code: 4637
Ordering Applications
Ordering Application Description
​Centricity ​NPM1 w/CEBPA if needed (4637)
​Cerner ​NPM1 w/CEBPA if needed (4637)
​COM ​NPM1 w/ CEBPA if needed
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Bone marrow ​EDTA Lavender Top Tube (LTT) ​ ​5 mL ​2 mL ​
​Whole blood EDTA Lavender Top Tube (LTT)​ ​ 5 mL​ ​2 mL ​
Collection Processing
​Submit sample at room temperature.
Specimen Stability Information
Specimen Type Temperature Time
​Bone marrow OR ​Whole blood ​Room temperature ​ ​7 days ​
Rejection Criteria
Samples not submitted in EDTA
Useful For

Useful for risk stratification in patients with cytogenetically normal Acute Myeloid Leukemia (AML).

Evaluation for familial AML.​

Reference Range Information
Interpretive report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Blood Center of Wisconsin​ Monday through Friday​

​NPM1: 3-6 days

CEBPA Reflex: 10-14 days

 PCR​
Reference Lab
Versiti/Blood Center of Wisconsin
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
81310​ ​ ​ NPM1 Mutation​ ​
81218​ ​ ​ CEBPA Analysis (if needed)​ ​
For most current information refer to the Marshfield Laboratory online reference manual.