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25208 UroVysion for Bladder Cancer Detection (FUROC)

UroVysion for Bladder Cancer Detection (FUROC)
Test Code: UROVYSO
Synonyms/Keywords
Bladder Cancer, FISH for Bladder Cancer, FISH for Upper Urinary Tract Cancer, FISH Urothelial Cancer, UroVysion, FURO, Cytology FISH
Useful For
Monitoring for tumor recurrence in patients with a history of urothelial carcinoma involving the bladder or upper urinary tract and for assessing patients with hematuria for urothelial carcinoma
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine​ ​Urocyte Urine Collection Kit ​30 mL 30 mL; but less than 30 mL will not be rejected​
Collection Processing Instructions
​Please call Marshfield Labs' Customer Service to obtain kits. Follow instructions included with the Urocyte Urine Collection Kit. If kit is not used, submit a random urine specimen with an equal volume of 70% ethanol, PreservCyt, or CytoLyt.
Specimen Stability Information
Specimen Type Temperature
​Urine ​ Refrigerated (preferred)​
​Ambient
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​ Monday through Sunday​ ​4 days
Fluorescence In Situ Hybridization (FISH) Using DNA Probes​
Reference Lab
Reference Range Information
Interpretive Report
Interpretation

Lower Tract Samples:

Abnormal: any specimen satisfying 1 of the following criteria:

-Four or more cells with gains of 2 or more chromosomes

-Ten or more cells with a gain of a single chromosome or 10 or more cells with tetrasomic signal patterns (ie, 4 copies for each of the 4 probes)

-Homozygous deletion of the 9p21 locus in 20% or more of the cells analyzed

 

For cases that are abnormal, the percentage of abnormal cells and type of chromosomal abnormality (ie, polysomy, trisomy, tetrasomy, or homozygous 9p21 deletion) are indicated in the test report.

Negative:

-Fewer than 4 cells with gains of 2 or more chromosomes

-Fewer than 10 cells with gain of a single chromosome or tetrasomy

-Less than 20% of cells with homozygous 9p21 deletion

 

Upper Tract Samples:

Abnormal: any upper tract specimen satisfying 1 of the following criteria:

-Four or more hypertetrasomy cells with at least 5 copies of 2 or more chromosomes

-Ten or more cells with a gain of a single chromosome or 10% or more cells with tetrasomic or near-tetrasomic signal patterns (ie, 4 copies for each of the 4 probes)

-Homozygous deletion of the 9p21 locus in 20% or more of the cells analyzed

 

Negative:

-Fewer than 4 cells with hypertetrasomy with at least 5 copies of 2 or more chromosomes

-Fewer than 10% of cells with tetrasomy

-Less than 20% of cells with homozygous 9p21 deletion

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88120​
Synonyms/Keywords
Bladder Cancer, FISH for Bladder Cancer, FISH for Upper Urinary Tract Cancer, FISH Urothelial Cancer, UroVysion, FURO, Cytology FISH
Ordering Applications
Ordering Application Description
​Centricity ​UroVysion for Bladder Ca Detection (FURO)
​Cerner None​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine​ ​Urocyte Urine Collection Kit ​30 mL 30 mL; but less than 30 mL will not be rejected​
Collection Processing
​Please call Marshfield Labs' Customer Service to obtain kits. Follow instructions included with the Urocyte Urine Collection Kit. If kit is not used, submit a random urine specimen with an equal volume of 70% ethanol, PreservCyt, or CytoLyt.
Specimen Stability Information
Specimen Type Temperature
​Urine ​ Refrigerated (preferred)​
​Ambient
Useful For
Monitoring for tumor recurrence in patients with a history of urothelial carcinoma involving the bladder or upper urinary tract and for assessing patients with hematuria for urothelial carcinoma
Reference Range Information
Interpretive Report
Interpretation

Lower Tract Samples:

Abnormal: any specimen satisfying 1 of the following criteria:

-Four or more cells with gains of 2 or more chromosomes

-Ten or more cells with a gain of a single chromosome or 10 or more cells with tetrasomic signal patterns (ie, 4 copies for each of the 4 probes)

-Homozygous deletion of the 9p21 locus in 20% or more of the cells analyzed

 

For cases that are abnormal, the percentage of abnormal cells and type of chromosomal abnormality (ie, polysomy, trisomy, tetrasomy, or homozygous 9p21 deletion) are indicated in the test report.

Negative:

-Fewer than 4 cells with gains of 2 or more chromosomes

-Fewer than 10 cells with gain of a single chromosome or tetrasomy

-Less than 20% of cells with homozygous 9p21 deletion

 

Upper Tract Samples:

Abnormal: any upper tract specimen satisfying 1 of the following criteria:

-Four or more hypertetrasomy cells with at least 5 copies of 2 or more chromosomes

-Ten or more cells with a gain of a single chromosome or 10% or more cells with tetrasomic or near-tetrasomic signal patterns (ie, 4 copies for each of the 4 probes)

-Homozygous deletion of the 9p21 locus in 20% or more of the cells analyzed

 

Negative:

-Fewer than 4 cells with hypertetrasomy with at least 5 copies of 2 or more chromosomes

-Fewer than 10% of cells with tetrasomy

-Less than 20% of cells with homozygous 9p21 deletion

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​ Monday through Sunday​ ​4 days
Fluorescence In Situ Hybridization (FISH) Using DNA Probes​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88120​
For most current information refer to the Marshfield Laboratory online reference manual.