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25250 Myelodysplastic Syndrome (MDS) FISH (MDSF)

Myelodysplastic Syndrome (MDS) FISH (MDSF)
Test Code: FMDSSO
Synonyms/Keywords
​​​​​MDS
Useful For

​ - Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with myelodysplastic syndromes or other myeloid malignancies.

 - Evaluating specimens in which standard cytogenetic analysis is unsuccesful.

 - Identifying and tracking known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
 Submit only 1 of the following specimens:​ ​ ​ ​ ​ ​
​No ​Whole Blood Sodium Heparin ​Green Top Tube (GTT) ​ ​7-10 mL ​2 mL ​
​ ​Bone Marrow Sodium Heparin ​Green Top Tube (GTT)​ ​ 1-2 mL​ ​1 mL ​
Collection Processing Instructions
1. Invert several times to mix blood.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Stability Information
Specimen Type Temperature
​Blood or Bone Marrow ​Ambient (preferred)
​ ​Refrigerate
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Sunday​ ​7 days ​Cytogenic DNA
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
88291 ​ 1 ​​Interpretation and report ​
​88271 ​ 2 Probe Set, 1ST ​​
​88271​ ​ 2 ​Probe, +2 ​​as needed
​​88271 ​ ​1 ​Probe, +1 ​​as needed
​​88271 ​ ​2 ​Probe, +2 ​​as needed
​​88271 ​ ​3 ​Probe, +3 ​​as needed
​​88274 ​ ​1 ​Interphases, <25​ ​​as needed
​​88274 ​ ​1 ​Interphases, 25-99 ​​as needed
​​88275 ​ ​1 ​Interphases, >100 ​​as needed
Synonyms/Keywords
​​​​​MDS
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
 Submit only 1 of the following specimens:​ ​ ​ ​ ​ ​
​No ​Whole Blood Sodium Heparin ​Green Top Tube (GTT) ​ ​7-10 mL ​2 mL ​
​ ​Bone Marrow Sodium Heparin ​Green Top Tube (GTT)​ ​ 1-2 mL​ ​1 mL ​
Collection Processing
1. Invert several times to mix blood.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Stability Information
Specimen Type Temperature
​Blood or Bone Marrow ​Ambient (preferred)
​ ​Refrigerate
Useful For

​ - Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with myelodysplastic syndromes or other myeloid malignancies.

 - Evaluating specimens in which standard cytogenetic analysis is unsuccesful.

 - Identifying and tracking known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy.

Reference Range Information
Performing Location Reference Range
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Sunday​ ​7 days ​Cytogenic DNA
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
88291 ​ 1 ​​Interpretation and report ​
​88271 ​ 2 Probe Set, 1ST ​​
​88271​ ​ 2 ​Probe, +2 ​​as needed
​​88271 ​ ​1 ​Probe, +1 ​​as needed
​​88271 ​ ​2 ​Probe, +2 ​​as needed
​​88271 ​ ​3 ​Probe, +3 ​​as needed
​​88274 ​ ​1 ​Interphases, <25​ ​​as needed
​​88274 ​ ​1 ​Interphases, 25-99 ​​as needed
​​88275 ​ ​1 ​Interphases, >100 ​​as needed
For most current information refer to the Marshfield Laboratory online reference manual.