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25481 HPV-Human Papillomavirus Genotyping 16, 18/45(NAM)

HPV-Human Papillomavirus Genotyping 16, 18/45(NAM)
Test Code: HPVGENO
Synonyms/Keywords
HPV, ThinPrep, Genotyping
Useful For
HPV Genotyping should only be ordered on samples that have tested positive for high risk HPV(HR-HPV). The currently recommended indication for HPV genotyping is in cases when a woman has had a normal cervical cytology result in conjunction with a HR-HPV positive result.  If HPV genotyping reveals the presence of HPV 16 or 18/45 the patient should be referred to colposcopy.  If HPV genotyping does not reveal HPV 16 or 18/45 the patient should have cytology and HR-HPV testing performed again in 12 months.  
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)​​
​No ​Cervical/Vaginal spatula/cytobrush ​ThinPrep Vial ​Green Label Aptima Tube ​1 mL ​1 mL ​
Collection Processing Instructions

Cervical specimens obtained using a spatula/cytobrush collection device and placed in ThinPrep vial containing PreservCyt solution. Transport ThinPrep specimen at room temperature overnight.

Samples submitted in green label Aptima tubes containing 1.0 mL of PreservCyt solution will be accepted if the sample previously tested positive for High Risk HPV.

Acceptable Body Sites

Default: CERVICAL-VAGINAL

Allowed: CERVICAL-VAGINAL, CERVIX, CERVIX-ENOCERVIX, ENDOCERVICAL, ENDOMETRIUM, LATERAL WALL, OTHER, VAGINAL, VAGINAL CUFF, VAGINAL VAULT, VULVA

Acceptable Specimen Types
​Cervical/Vaginal ThinPrep
Specimen Stability Information
Specimen Type Temperature Tim​​e
​ThinPrep ​Ambient ​30 days
​Aptima Specimen ​Ambient ​60 days
Rejection Criteria

​Insufficient amount (less than 1 mL)

​Samples in Sure Path collection vials
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrum​​entation
​Marshfield ​Wednesday
6-8 hours*
 ​Transcription-Mediated Amplification (TMA)
*Testing performed once/week.
​ ​Sample must be re​ceived in the lab by 0400 Wednesday to be tested same day.​ ​ ​ ​ ​
Test Information
HPV Genotyping should only be ordered on samples that have tested positive for high risk HPV. If Marshfield Labs performed the HPV nucleic acid testing within the last 20 days, please call the Molecular Pathology lab section at 715-221-6191 to have the HPV sample retrieved for this testing request. Marshfield Labs Molecular Pathology section is staffed Monday – Friday (0400-1700). If there is no answer at this phone number, please leave your name and contact phone number so staff can contact you for patient order information.
Reference Range Information
See Report
Interpretation
Reported as Negative, Positive or Indeterminate for HPV Genotype 16, 18/45 in cervical specimens by TMA.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comme​​nts
​87625 ​ ​ ​ ​
Synonyms/Keywords
HPV, ThinPrep, Genotyping
Ordering Applications
Ordering Application Descrip​​tion
Clinical Order Manager​ ​HPV Genotyping 16, 18/45 (NAM)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)​​
​No ​Cervical/Vaginal spatula/cytobrush ​ThinPrep Vial ​Green Label Aptima Tube ​1 mL ​1 mL ​
Collection Processing

Cervical specimens obtained using a spatula/cytobrush collection device and placed in ThinPrep vial containing PreservCyt solution. Transport ThinPrep specimen at room temperature overnight.

Samples submitted in green label Aptima tubes containing 1.0 mL of PreservCyt solution will be accepted if the sample previously tested positive for High Risk HPV.

Acceptable Body Sites

Default: CERVICAL-VAGINAL

Allowed: CERVICAL-VAGINAL, CERVIX, CERVIX-ENOCERVIX, ENDOCERVICAL, ENDOMETRIUM, LATERAL WALL, OTHER, VAGINAL, VAGINAL CUFF, VAGINAL VAULT, VULVA

Acceptable Specimen Types
​Cervical/Vaginal ThinPrep
Specimen Stability Information
Specimen Type Temperature Tim​​e
​ThinPrep ​Ambient ​30 days
​Aptima Specimen ​Ambient ​60 days
Rejection Criteria

​Insufficient amount (less than 1 mL)

​Samples in Sure Path collection vials
Useful For
HPV Genotyping should only be ordered on samples that have tested positive for high risk HPV(HR-HPV). The currently recommended indication for HPV genotyping is in cases when a woman has had a normal cervical cytology result in conjunction with a HR-HPV positive result.  If HPV genotyping reveals the presence of HPV 16 or 18/45 the patient should be referred to colposcopy.  If HPV genotyping does not reveal HPV 16 or 18/45 the patient should have cytology and HR-HPV testing performed again in 12 months.  
Reference Range Information
See Report
Interpretation
Reported as Negative, Positive or Indeterminate for HPV Genotype 16, 18/45 in cervical specimens by TMA.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrum​​entation
​Marshfield ​Wednesday
6-8 hours*
 ​Transcription-Mediated Amplification (TMA)
*Testing performed once/week.
​ ​Sample must be re​ceived in the lab by 0400 Wednesday to be tested same day.​ ​ ​ ​ ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comme​​nts
​87625 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.