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25594 N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer (2005164)

N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer (2005164)
Test Code: NMDARSO
Synonyms/Keywords

anti-GluN1, Anti-NMDA CSF, anti-NR1, Glutamate Receptor Antibodies, N-Methyl D-Aspartate Ab CSF, NMDA R, NMDA Receptor Ab CSF

Useful For

Confirm diagnosis of anti-NMDAR encephalitis.

May be used in monitoring treatment response in individuals who are antibody positive.  

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Sterile tube ​ ​0.5 mL ​0.15 mL ​
Collection Processing Instructions
​Transport refrigerated
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Ambient ​48 hours
​Refrigerated ​2 weeks
​Frozen ​1 year (avoid repeated freeze/thaw cycles)
Rejection Criteria
Contaminated Specimens
​Hemolyzed Specimens
​Severely Lipemic Specimens
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​ARUP ​Sunday through Saturday ​1-3 days ​Semi-Quantitative Indirect Fluorescent Antibody
Reference Lab
ARUP Laboratories
Test Information

​Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

Reference Range Information

​<1:1

Interpretation

If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86255 ​ ​1 ​Fluorescent antibody screen ​
​86256 ​ ​1 ​Fluorescent antibody titer ​If Reflexed
Synonyms/Keywords

anti-GluN1, Anti-NMDA CSF, anti-NR1, Glutamate Receptor Antibodies, N-Methyl D-Aspartate Ab CSF, NMDA R, NMDA Receptor Ab CSF

Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Sterile tube ​ ​0.5 mL ​0.15 mL ​
Collection Processing
​Transport refrigerated
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Ambient ​48 hours
​Refrigerated ​2 weeks
​Frozen ​1 year (avoid repeated freeze/thaw cycles)
Rejection Criteria
Contaminated Specimens
​Hemolyzed Specimens
​Severely Lipemic Specimens
Useful For

Confirm diagnosis of anti-NMDAR encephalitis.

May be used in monitoring treatment response in individuals who are antibody positive.  

Reference Range Information

​<1:1

Interpretation

If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​ARUP ​Sunday through Saturday ​1-3 days ​Semi-Quantitative Indirect Fluorescent Antibody
Reference Lab
ARUP Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86255 ​ ​1 ​Fluorescent antibody screen ​
​86256 ​ ​1 ​Fluorescent antibody titer ​If Reflexed
For most current information refer to the Marshfield Laboratory online reference manual.