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25656 Syphilis Confirmation by RPR/TP-PA

Syphilis Confirmation by RPR/TP-PA
Test Code: SYPHOR
Synonyms/Keywords

​Syphilis Screen, Rapid Plasma Reagin (RPR), Treponemal pallidum Particle Agglutination (TP-PA), VDRL 

Test Components
​Syphilis Treponemal IgG Antibody Screen, Rapid Plasma Reagin (RPR) (if needed), Treponemal pallidum Particle Agglutination (TP-PA) (if needed)
Useful For
​Order this test if the patient has a positive antibody screen (IgG or IgM). The RPR will be performed. In case the results of the antibody testing disagree with the RPR, another treponemal test, Treponemal pallidum Particle Agglutination (TPPA) will be performed at an additional charge.
 
NOTE: The CDC and WHO recommend both a positive antibody test against the causative agent Treponema pallidum and a positive non-treponemal test such as the Rapid Plasma Reagin (RPR) before making a serological diagnosis of syphilis.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum ​Red Top Tube (RTT) or Serum Separator Tube (SST) ​1.0 mL ​0.5 mL ​0.5 mL
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate ​7 days
​Frozen ​> 7 days
Rejection Criteria
Gross hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​1 day ​Mulitplex Flow Immunoassay/ BioRad Bioplex 2200
OR
RPR (Rapid Plasma Reagin) Flocculation Test​
Reference Range Information
Performing Location Reference Range
​Marshfield ​Negative
Interpretation
​Link to: Syphilis Testing Algorithm
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86593​ ​ ​1 ​RPR ​
86780​ ​ ​1 ​TP-PA (if needed) ​
Synonyms/Keywords

​Syphilis Screen, Rapid Plasma Reagin (RPR), Treponemal pallidum Particle Agglutination (TP-PA), VDRL 

Test Components
​Syphilis Treponemal IgG Antibody Screen, Rapid Plasma Reagin (RPR) (if needed), Treponemal pallidum Particle Agglutination (TP-PA) (if needed)
Ordering Applications
Ordering Application Description
​COM ​Syphilis Confirmation by RPR/TP-PA
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum ​Red Top Tube (RTT) or Serum Separator Tube (SST) ​1.0 mL ​0.5 mL ​0.5 mL
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate ​7 days
​Frozen ​> 7 days
Rejection Criteria
Gross hemolysis
Useful For
​Order this test if the patient has a positive antibody screen (IgG or IgM). The RPR will be performed. In case the results of the antibody testing disagree with the RPR, another treponemal test, Treponemal pallidum Particle Agglutination (TPPA) will be performed at an additional charge.
 
NOTE: The CDC and WHO recommend both a positive antibody test against the causative agent Treponema pallidum and a positive non-treponemal test such as the Rapid Plasma Reagin (RPR) before making a serological diagnosis of syphilis.
Test Components
​Syphilis Treponemal IgG Antibody Screen, Rapid Plasma Reagin (RPR) (if needed), Treponemal pallidum Particle Agglutination (TP-PA) (if needed)
Reference Range Information
Performing Location Reference Range
​Marshfield ​Negative
Interpretation
​Link to: Syphilis Testing Algorithm
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​1 day ​Mulitplex Flow Immunoassay/ BioRad Bioplex 2200
OR
RPR (Rapid Plasma Reagin) Flocculation Test​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86593​ ​ ​1 ​RPR ​
86780​ ​ ​1 ​TP-PA (if needed) ​
For most current information refer to the Marshfield Laboratory online reference manual.