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26024 Osteocalcin, Serum (OSCAL)

Osteocalcin, Serum (OSCAL)
Test Code: OSCALSO
Synonyms/Keywords
N-MID Osteocalcin, Osteocalcin
Useful For

Monitoring and assessing effectiveness of antiresorptive therapy in patients treated for osteopenia, osteoporosis, Paget's disease, or other disorders in which osteocalcin levels are elevated.

As an adjunct in the diagnosis of medical conditions associated with increased bone turnover, including Paget's disease, cancer accompanied by bone metastases, primary hyperparathyroidism, and renal osteodystrophy.

This test is not useful for the diagnosis of osteoporosis. 

Specimen Requirements
​FastingSpecimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Yes-12 hours​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.75 mL
Collection Processing Instructions
Twelve hours before this blood test, do not take multivitamins or dietary supplements containing biotin or vitamin B7 that are commonly found in hair, skin and nail supplements and multivitamins.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Frozen (preferred) ​14 days
​Refrigerate ​72 hours
Rejection Criteria
Gross Hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Saturday ​1 day ​Electrochemiluminescence Immunoassay
Reference Lab
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories

Males

<5 years: 19-75 ng/mL

5-9 years: 21-108 ng/mL

10-15 years: 19-159 ng/mL

16-17: 12-114 ng/mL

> or =18 years: 9-42 ng/mL

 

Females

<5 years: 14-126 ng/mL

5-9 years: 16-152 ng/mL

10-15 years: 15-151 ng/mL

16-17 years: 9-70 ng/mL

> or =18 years: 9-42 ng/mL

Interpretation
Elevated levels of osteocalcin indicate increased bone turnover. In patients taking antiresorptive agents (bisphosphonates or hormone replacement therapy), a decrease of 20% or less from baseline osteocalcin level (ie, prior to the start of therapy) after 3 to 6 months of therapy, suggests effective response to treatment. Patients with diseases such as hyperparathyroidism, which can be cured, should have a return of osteocalcin levels to the reference range within 3 to 6 months after complete cure.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83937 ​1
Synonyms/Keywords
N-MID Osteocalcin, Osteocalcin
Ordering Applications
Ordering Application Description
​COM Osteocalcin, Serum (OSCAL)
​Centricity Osteocalcin, Serum (OSCAL)
​Cerner Osteocalcin, Serum (OSCAL)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
​FastingSpecimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Yes-12 hours​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.75 mL
Collection Processing
Twelve hours before this blood test, do not take multivitamins or dietary supplements containing biotin or vitamin B7 that are commonly found in hair, skin and nail supplements and multivitamins.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Frozen (preferred) ​14 days
​Refrigerate ​72 hours
Rejection Criteria
Gross Hemolysis
Useful For

Monitoring and assessing effectiveness of antiresorptive therapy in patients treated for osteopenia, osteoporosis, Paget's disease, or other disorders in which osteocalcin levels are elevated.

As an adjunct in the diagnosis of medical conditions associated with increased bone turnover, including Paget's disease, cancer accompanied by bone metastases, primary hyperparathyroidism, and renal osteodystrophy.

This test is not useful for the diagnosis of osteoporosis. 

Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories

Males

<5 years: 19-75 ng/mL

5-9 years: 21-108 ng/mL

10-15 years: 19-159 ng/mL

16-17: 12-114 ng/mL

> or =18 years: 9-42 ng/mL

 

Females

<5 years: 14-126 ng/mL

5-9 years: 16-152 ng/mL

10-15 years: 15-151 ng/mL

16-17 years: 9-70 ng/mL

> or =18 years: 9-42 ng/mL

Interpretation
Elevated levels of osteocalcin indicate increased bone turnover. In patients taking antiresorptive agents (bisphosphonates or hormone replacement therapy), a decrease of 20% or less from baseline osteocalcin level (ie, prior to the start of therapy) after 3 to 6 months of therapy, suggests effective response to treatment. Patients with diseases such as hyperparathyroidism, which can be cured, should have a return of osteocalcin levels to the reference range within 3 to 6 months after complete cure.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Saturday ​1 day ​Electrochemiluminescence Immunoassay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83937 ​1
For most current information refer to the Marshfield Laboratory online reference manual.