Evaluating patients suspected of having systemic sclerosis, when used in conjunction with centromere and Scl70 antibodies.
Providing diagnostic and prognostic information in patients with systemic sclerosis.
A positive result supports a possible diagnosis of systemic sclerosis (see Cautions). This autoantibody is strongly associated with diffuse cutaneous scleroderma and with an increased risk of acute renal crisis.
A negative result indicates no detectable IgG antibodies to RNA polymerase III, but does not rule out the possibility of systemic sclerosis (11%-23% sensitivity).