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26154 Targeted Drug Panel, Urine

Targeted Drug Panel, Urine
Test Code: TDPU
Synonyms/Keywords
Drug screen, drug test, amines, amphetamine, methamphetamine, benzodiazepines, opiates, opioids
Test Components

Definitive/confirmatory panel to semi-quantitatively detect the use of amines/amphetamines, benzodiazepines, and opioids drug classes using Liquid Chromatography-Tandem Mass Spectrometry methodology. Quantitative results are not available, but drugs detected as “present” will be reported with a quantitative range in which it was detected.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Useful For
Qualitative, definitive urine drug test for the amines, benzodiazepines, and opioids drug classes.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Urine​Clean plastic container ​ ​5 mL ​0.5 mL ​0.25 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​ ​ ​Refrigerate (preferred) ​30 days
​Frozen ​30 days
​Ambient ​7 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​2 days ​Waters TQ/XS Liquid Chromatography - Tandems Mass Spec system
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
  

​This assay is a semi-quantitative confirmatory test by liquid chromatography/tandem mass spectrometry (LC/MSMS). If an analyte or its corresponding metabolites are present in urine, it indicates that the patient has used the respective drugs recently. If a drug is detected, it will be reported as “present”, in three concentration ranges (low, moderate, and high) with the analyte’s specific ranges. The test includes seven amines: amphetamine, methamphetamine, MDA, MDMA, MDEA, methylphenidate, ritalinic acid; six benzodiazepines: 7-aminoclonazepam, lorazepam, oxazepam, alphahydroxyalprazolam, nordiazepam, temazepam; seventeen opiates: buprenorphine, norbuprenorphine (buprenorphine metabolite), oxycodone, nor-oxycodone (oxycodone metabolite), oxymorphone (oxycodone metabolite), morphine, hydromorphone, 6-monoacetylmorphine (heroin metabolite), codeine, hydrocodone, gabapentin, tramadol, nor-tramadol (tramadol metabolite), fentanyl, nor-fentanyl (fentanyl metabolite), EDDP (methadone metabolite), and methadone. Analytes below the level of detection level will be reported as “not detected”.

This test is developed in-house with targeted analytes in consultation with pain management providers. The objective of this test is to provide useful information to help determine patient compliance or identify misuse of other drugs commonly present in our patient population.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Reference Range Information
Performing Location Reference Range
​Marshfield ​No reference range for drugs found in urine.  Presence of drug indicates ingestion/use only, and is not to be used for therapeutic drug monitoring.
Interpretation

Drugs are reported as “Present” or “Not Detected”. Drugs reported as “Present” are also reported as present at a “Low”, “Moderate”, or “High” level.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components 

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​G0481 ​ ​1 ​Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to GC/MS (any type, single or tandem) and LC/MS (any type, single or tandem and excluding immunoassays (e.g., IA, EIA, ELISA, EMIT, FPIA) and enzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or other universally recognized internal standards in all samples (e.g., to control for matrix effects, interferences and variations in signal strength), and (3) method or drug-specific calibration and matrix-matched quality control material (e.g., to control for instrument variations and mass spectral drift); qualitative or quantitative, all sources, includes specimen validity testing, per day; 8-14 drug class(es), including metabolite(s) if performed. ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
Drug screen, drug test, amines, amphetamine, methamphetamine, benzodiazepines, opiates, opioids
Test Components

Definitive/confirmatory panel to semi-quantitatively detect the use of amines/amphetamines, benzodiazepines, and opioids drug classes using Liquid Chromatography-Tandem Mass Spectrometry methodology. Quantitative results are not available, but drugs detected as “present” will be reported with a quantitative range in which it was detected.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Ordering Applications

Ordering Application Description
​Cerner ​Targeted Drug Panel, Urine

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Urine​Clean plastic container ​ ​5 mL ​0.5 mL ​0.25 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​ ​ ​Refrigerate (preferred) ​30 days
​Frozen ​30 days
​Ambient ​7 days
Useful For
Qualitative, definitive urine drug test for the amines, benzodiazepines, and opioids drug classes.
Test Components

Definitive/confirmatory panel to semi-quantitatively detect the use of amines/amphetamines, benzodiazepines, and opioids drug classes using Liquid Chromatography-Tandem Mass Spectrometry methodology. Quantitative results are not available, but drugs detected as “present” will be reported with a quantitative range in which it was detected.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Reference Range Information
Performing Location Reference Range
​Marshfield ​No reference range for drugs found in urine.  Presence of drug indicates ingestion/use only, and is not to be used for therapeutic drug monitoring.
Interpretation

Drugs are reported as “Present” or “Not Detected”. Drugs reported as “Present” are also reported as present at a “Low”, “Moderate”, or “High” level.

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components 

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday ​2 days ​Waters TQ/XS Liquid Chromatography - Tandems Mass Spec system
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​G0481 ​ ​1 ​Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to GC/MS (any type, single or tandem) and LC/MS (any type, single or tandem and excluding immunoassays (e.g., IA, EIA, ELISA, EMIT, FPIA) and enzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or other universally recognized internal standards in all samples (e.g., to control for matrix effects, interferences and variations in signal strength), and (3) method or drug-specific calibration and matrix-matched quality control material (e.g., to control for instrument variations and mass spectral drift); qualitative or quantitative, all sources, includes specimen validity testing, per day; 8-14 drug class(es), including metabolite(s) if performed. ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.