Apolipoprotein A1, Serum (APOA1)

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Test Code: APLA1SO

Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding

Synonyms/Keywords

Apo A, ApoA-1, Apo A1, ApoA, ApoA-1, ApoA1, Apolipoprotein A, Apolipoprotein A-I, Apolipoprotein A1, Apolipoprotein AI

Useful For

Evaluation of risk for atherosclerotic cardiovascular disease.

Helpful to aid in the detection of Tangier disease.

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	0.5 mL	0.5 mL

Collection Processing Instructions

Centrifuge and aliquot within 2 hours of collection. Red Top Tubes should be centrifuged and aliquoted within 2 hours of collection.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	8 days
	Frozen	60 days
	Ambient	24 hours

Rejection Criteria

Gross Hemolysis
Gross Icterus

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Report Available	Methodology/Instrumentation
Mayo Clinic Laboratories	Monday through Sunday	1 to 2 days	Automated Turbidimetric Immunoassay

Reference Lab

Mayo Clinic Laboratories

Reference Range Information

Performing Location	Reference Range
Mayo Clinic Laboratories	Males <24 months: not established 2-17 years: Low: <115 mg/dL Borderline low: 115-120 mg/ dl Acceptable: >120 mg/dL >18 years: >=120 mg/dl Females <24 months: not established 2-17 years: Low: <115 mg/dl Borderline low: 115-120 mg/dL Acceptable: >120 mg/dL >18 years: >=140 mg/dl

Performing Location

Reference Range

Mayo Clinic Laboratories

Males

<24 months: not established

2-17 years:

Low: <115 mg/dL

Borderline low: 115-120 mg/ dl

Acceptable: >120 mg/dL

>18 years: >=120 mg/dl

Females

<24 months: not established

2-17 years:

Low: <115 mg/dl

Borderline low: 115-120 mg/dL

Acceptable: >120 mg/dL

>18 years: >=140 mg/dl

Interpretation

Low levels of apolipoprotein Al (ApoAl) confer increased risk of atherosclerotic cardiovascular disease.

ApoA1 below 25 mg/dL may aid in the detection of a genetic disorder such as Tangier disease.

ApoA1 is often interpreted as a ratio with apolipoprotein B (ApoB).

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
82172		1

Synonyms/Keywords

Apo A, ApoA-1, Apo A1, ApoA, ApoA-1, ApoA1, Apolipoprotein A, Apolipoprotein A-I, Apolipoprotein A1, Apolipoprotein AI

Ordering Applications

Ordering Application	Description
Cerner	Apolipoprotein A1, S (APOA1)
COM	Apolipoprotein A1, S (APOA1)

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	0.5 mL	0.5 mL

Collection Processing

Centrifuge and aliquot within 2 hours of collection. Red Top Tubes should be centrifuged and aliquoted within 2 hours of collection.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	8 days
	Frozen	60 days
	Ambient	24 hours

Rejection Criteria

Gross Hemolysis
Gross Icterus

Useful For

Evaluation of risk for atherosclerotic cardiovascular disease.

Helpful to aid in the detection of Tangier disease.

Reference Range Information

Performing Location	Reference Range
Mayo Clinic Laboratories	Males <24 months: not established 2-17 years: Low: <115 mg/dL Borderline low: 115-120 mg/ dl Acceptable: >120 mg/dL >18 years: >=120 mg/dl Females <24 months: not established 2-17 years: Low: <115 mg/dl Borderline low: 115-120 mg/dL Acceptable: >120 mg/dL >18 years: >=140 mg/dl

Performing Location

Reference Range

Mayo Clinic Laboratories

Males

<24 months: not established

2-17 years:

Low: <115 mg/dL

Borderline low: 115-120 mg/ dl

Acceptable: >120 mg/dL

>18 years: >=120 mg/dl

Females

<24 months: not established

2-17 years:

Low: <115 mg/dl

Borderline low: 115-120 mg/dL

Acceptable: >120 mg/dL

>18 years: >=140 mg/dl

Interpretation

Low levels of apolipoprotein Al (ApoAl) confer increased risk of atherosclerotic cardiovascular disease.

ApoA1 below 25 mg/dL may aid in the detection of a genetic disorder such as Tangier disease.

ApoA1 is often interpreted as a ratio with apolipoprotein B (ApoB).

For more information visit:

http://labtestsonline.org

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Report Available	Methodology/Instrumentation
Mayo Clinic Laboratories	Monday through Sunday	1 to 2 days	Automated Turbidimetric Immunoassay

Reference Lab

Mayo Clinic Laboratories

For billing questions, see Contacts

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
82172		1

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For most current information refer to the Marshfield Laboratory online reference manual.

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26158 Apolipoprotein A1, Serum (APOA1)