PSA, Total Hybritech

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Marshfield Clinic Public WebSite

Test Code: PSA-H

Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding

Synonyms/Keywords

Prostate Specific Antigen, Total Hybritech

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	0.5 mL	0.4 mL	0.3 mL

Collection Processing Instructions

Remove from cells within 2 hours of centrifugation.

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of blood sample.

Plasma is not preferred per manufacturer IFU, but internal Marshfield sample type study showed plasma can be used if only sample available.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Ambient	8 hours
	Refrigerated	24 hours
	Frozen	>24 hours, up to 5 months

Interference

Human Anti-Murine Antibodies (HAMA) may develop leading to interference in patients receiving murine-based agents for chemotherapy or tumor-imaging studies.

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Eau Claire	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Marshfield	Monday thorough Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Minocqua	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Rice Lake	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI

Reference Range Information

Performing Location	Reference Range
All Performing Sites	Males < = 49 years: 0.0 - 2.5 ng/mL Males 50-59 years: 0.0 - 3.5 ng/mL Males > = 60 years: 0.0 - 4.0 ng/mL

Performing Location

Reference Range

All Performing Sites

Males < = 49 years: 0.0 - 2.5 ng/mL

Males 50-59 years: 0.0 - 3.5 ng/mL

Males > = 60 years: 0.0 - 4.0 ng/mL

Interpretation

Marshfield campus PSA assay shows improved sensitivity with a lower limit of detection of <0.03 ng/mL. Results in the range of 0-2 will be reported to two decimal places enabling improved monitoring of post-prostectomy patients.

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
84153

Synonyms/Keywords

Prostate Specific Antigen, Total Hybritech

Ordering Applications

Ordering Application	Description
Cerner	PSA, Total Hybritech

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	0.5 mL	0.4 mL	0.3 mL

Collection Processing

Remove from cells within 2 hours of centrifugation.

Plasma is not preferred per manufacturer IFU, but internal Marshfield sample type study showed plasma can be used if only sample available.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Ambient	8 hours
	Refrigerated	24 hours
	Frozen	>24 hours, up to 5 months

Interference

Human Anti-Murine Antibodies (HAMA) may develop leading to interference in patients receiving murine-based agents for chemotherapy or tumor-imaging studies.

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.

Reference Range Information

Performing Location	Reference Range
All Performing Sites	Males < = 49 years: 0.0 - 2.5 ng/mL Males 50-59 years: 0.0 - 3.5 ng/mL Males > = 60 years: 0.0 - 4.0 ng/mL

Performing Location

Reference Range

All Performing Sites

Males < = 49 years: 0.0 - 2.5 ng/mL

Males 50-59 years: 0.0 - 3.5 ng/mL

Males > = 60 years: 0.0 - 4.0 ng/mL

Interpretation

For more information visit:

http://labtestsonline.org

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Eau Claire	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Marshfield	Monday thorough Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Minocqua	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI
Rice Lake	Monday through Friday	Less than 2 hours	Hybritech Ab Total PSA/Beckman Coulter DXI

For billing questions, see Contacts

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
84153

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For most current information refer to the Marshfield Laboratory online reference manual.

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26332 PSA, Total Hybritech