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26361 Invitae Breast Cancer STAT Panel (50001)

Invitae Breast Cancer STAT Panel (50001)
Test Code: BRSTSO
Useful For

All genes on this panel have published medical management guidelines and are associated with defined hereditary cancer syndromes.

This test is appropriate for breast cancer patients with upcoming cancer-related breast surgeries and/or treatment where genetic testing may inform decisions such as lumpectomy versus mastectomy, single versus double mastectomy, or use of other treatments (such as use of PARP inhibitors or other chemotherapy regimens). Identification of a disease-causing variant may also guide testing and management of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

Specimen Requirements
Submit one of the following specimens:  ​ ​ ​ ​
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Whole Blood​EDTA Lavender Top Tube (LTT)​3 mL​1.5 mL
​No​Saliva​Oragene self collection kit​2 mL for OG500/OGD500 and 1 mL for OGD510
Collection Processing Instructions

Blood should be shipped overnight at room temperature. 

​Store saliva at room temperature, avoiding lengthy refrigeration. Although there are no special time requirements, we recommend that the specimen be mailed to Invitae soon after collection.

Saliva collected and stored in an OrageneTM self collection kit (OG500/OGD500/OGD510)

  • Please note that this kit requires 2 mL of saliva for OG500/OGD500 and 1 mL of saliva for OGD510, and involves active (not assisted) saliva donation.
Specimen Stability Information
​Specimen Type​Temperature​Time
SalivaAmbientNo special requirements
Whole Blood​ ​​Ambient​48 hours
​Refrigerated​14 days
Rejection Criteria
Hemolyzed, clotted, or frozen blood
​Blood or saliva from patients who have had an allogeneic (non-self donor) bone marrow transplant​​
​Blood or saliva from patients who have had an allogeneic (non-self donor) stem cell transplant​​
Blood or saliva from patients who had a blood transfusion less than two weeks prior to specimen collection​​
​Saliva in any other container other than Oragene kits
Assisted saliva and gDNA are not accepted​
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Invitae​Monday through Saturday​5 to 12 daysNext Generation Sequencing Deletion/Duplication Analysis
Reference Lab
Test Information

​The Invitae Breast Cancer STAT Panel includes up to 9 well-established genes that are associated with a significantly increased risk of developing breast cancer. Accelerated turnaround time (TAT) is needed because physicians and patients often want to make surgical and management decisions as quickly as possible. Individuals who are identified with an inherited pathogenic variant have a higher risk of developing another breast cancer and may choose more aggressive surgery and/or different treatment options based on genetic testing results.

All genes on this panel have published medical management guidelines and are associated with defined hereditary cancer syndromes.

This test is appropriate for breast cancer patients with upcoming cancer-related breast surgeries and/or treatment where genetic testing may inform decisions such as lumpectomy versus mastectomy, single versus double mastectomy, or use of other treatments (such as use of PARP inhibitors or other chemotherapy regimens). Identification of a disease-causing variant may also guide testing and management of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

Reference Range Information

An interpretive report will be provided

Interpretation

​An interpretive report will be provided

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​81162​1BRCA1, BRCA2 gene analysis; full sequence analysis and full duplication/deletion analysis
Ordering Applications
Ordering ApplicationDescription
​COM​Invitae Breast Cancer STAT Panel (#50001)
​Cerner​Invitae Breast Cancer STAT Panel (#50001)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Submit one of the following specimens:  ​ ​ ​ ​
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Whole Blood​EDTA Lavender Top Tube (LTT)​3 mL​1.5 mL
​No​Saliva​Oragene self collection kit​2 mL for OG500/OGD500 and 1 mL for OGD510
Collection Processing

Blood should be shipped overnight at room temperature. 

​Store saliva at room temperature, avoiding lengthy refrigeration. Although there are no special time requirements, we recommend that the specimen be mailed to Invitae soon after collection.

Saliva collected and stored in an OrageneTM self collection kit (OG500/OGD500/OGD510)

  • Please note that this kit requires 2 mL of saliva for OG500/OGD500 and 1 mL of saliva for OGD510, and involves active (not assisted) saliva donation.
Specimen Stability Information
​Specimen Type​Temperature​Time
SalivaAmbientNo special requirements
Whole Blood​ ​​Ambient​48 hours
​Refrigerated​14 days
Rejection Criteria
Hemolyzed, clotted, or frozen blood
​Blood or saliva from patients who have had an allogeneic (non-self donor) bone marrow transplant​​
​Blood or saliva from patients who have had an allogeneic (non-self donor) stem cell transplant​​
Blood or saliva from patients who had a blood transfusion less than two weeks prior to specimen collection​​
​Saliva in any other container other than Oragene kits
Assisted saliva and gDNA are not accepted​
Useful For

All genes on this panel have published medical management guidelines and are associated with defined hereditary cancer syndromes.

This test is appropriate for breast cancer patients with upcoming cancer-related breast surgeries and/or treatment where genetic testing may inform decisions such as lumpectomy versus mastectomy, single versus double mastectomy, or use of other treatments (such as use of PARP inhibitors or other chemotherapy regimens). Identification of a disease-causing variant may also guide testing and management of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

Reference Range Information

An interpretive report will be provided

Interpretation

​An interpretive report will be provided

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Invitae​Monday through Saturday​5 to 12 daysNext Generation Sequencing Deletion/Duplication Analysis
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​81162​1BRCA1, BRCA2 gene analysis; full sequence analysis and full duplication/deletion analysis
For most current information refer to the Marshfield Laboratory online reference manual.