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26420 11-Deoxycortisol, Serum (DCORT)

11-Deoxycortisol, Serum (DCORT)
Test Code: DCORTSO
Synonyms/Keywords

​11-Deoxycortisol, 11-Deoxycorticosteroid, Cortodoxone, INN, USAN, BAN, 11-Desoxycortisol, 17-hydroxy-11-deoxycorticosterone, Compound B, Compound S, Corticosterone, Deoxycortisol, Tetrahydro S, Cortoxelone

Useful For

Diagnostic workup of patients with congenital adrenal hyperplasia

Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency

Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum​Red Top Tube (RTT)​Serum Separator Tube (SST)​0.5 mL​0.4 mL
Collection Processing Instructions

​Indicate if specimen was drawn before or after metyrapone.

Morning (8 a.m.) specimen is preferred.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​28 days
​Ambient​28 days
​Frozen​28 days
Rejection Criteria
Gross hemolysis
Interference

​Ethanol, estrogens (exogenous and pregnancy-related), barbiturates, valproic acid, phenytoin, and exogenous gluco-corticoids may cause impaired response to metyrapone.

There have been occasional reports of Addisonian crisis during 2-day metyrapone testing. For this reason, 2-day metyrapone testing probably should not be performed when plasma cortisol values are less than 3 mcg/dL.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Tuesday​3 to 9 days​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

< or =18 years: <344 ng/dL

>18 years: 10-79 ng/dL

Interpretation

In a patient suspected of having congenital adrenal hyperplasia (CAH), elevated serum 11-deoxycortisol levels indicate possible 11 beta-hydroxylase deficiency. However, not all patients will show baseline elevations in serum 11-deoxycortisol levels. In a significant proportion of cases, increases in 11-deoxycortisol levels are only apparent after adrenocorticotropic hormone (ACTH)(1-24) stimulation.(1)

Serum 11-deoxycortisol levels below 1,700 ng/dL 8 hours after metyrapone administration is indicative of probable adrenal insufficiency. The test cannot reliably distinguish between primary and secondary or tertiary causes of adrenal failure, as neither patients with pituitary failure, nor those with primary adrenocortical failure, tend to show an increase of 11-deoxycortisol levels after metyrapone is administered.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​82634​1
Synonyms/Keywords

​11-Deoxycortisol, 11-Deoxycorticosteroid, Cortodoxone, INN, USAN, BAN, 11-Desoxycortisol, 17-hydroxy-11-deoxycorticosterone, Compound B, Compound S, Corticosterone, Deoxycortisol, Tetrahydro S, Cortoxelone

Ordering Applications
Ordering ApplicationDescription
​COM​11-Deoxycortisol, Serum (DCORT)
​Cerner​11-Deoxycortisol, Serum (DCORT)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum​Red Top Tube (RTT)​Serum Separator Tube (SST)​0.5 mL​0.4 mL
Collection Processing

​Indicate if specimen was drawn before or after metyrapone.

Morning (8 a.m.) specimen is preferred.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​28 days
​Ambient​28 days
​Frozen​28 days
Rejection Criteria
Gross hemolysis
Interference

​Ethanol, estrogens (exogenous and pregnancy-related), barbiturates, valproic acid, phenytoin, and exogenous gluco-corticoids may cause impaired response to metyrapone.

There have been occasional reports of Addisonian crisis during 2-day metyrapone testing. For this reason, 2-day metyrapone testing probably should not be performed when plasma cortisol values are less than 3 mcg/dL.

Useful For

Diagnostic workup of patients with congenital adrenal hyperplasia

Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency

Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

< or =18 years: <344 ng/dL

>18 years: 10-79 ng/dL

Interpretation

In a patient suspected of having congenital adrenal hyperplasia (CAH), elevated serum 11-deoxycortisol levels indicate possible 11 beta-hydroxylase deficiency. However, not all patients will show baseline elevations in serum 11-deoxycortisol levels. In a significant proportion of cases, increases in 11-deoxycortisol levels are only apparent after adrenocorticotropic hormone (ACTH)(1-24) stimulation.(1)

Serum 11-deoxycortisol levels below 1,700 ng/dL 8 hours after metyrapone administration is indicative of probable adrenal insufficiency. The test cannot reliably distinguish between primary and secondary or tertiary causes of adrenal failure, as neither patients with pituitary failure, nor those with primary adrenocortical failure, tend to show an increase of 11-deoxycortisol levels after metyrapone is administered.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Tuesday​3 to 9 days​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​82634​1
For most current information refer to the Marshfield Laboratory online reference manual.