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26475 Maternal Cell Contamination, Molecular Analysis, Varies (MATCC)

Maternal Cell Contamination, Molecular Analysis, Varies (MATCC)
Test Code: MCCSO
Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Useful For

Ruling out the presence of maternal cell contamination within a fetal specimen

Required for all prenatal testing performed in Mayo Clinic Laboratories' Molecular and Biochemical Genetics laboratories

GENETICS TEST INFORMATION: 

**Required in conjunction with molecular and biochemical prenatal testing only.**

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​ ​ ​When this test is ordered both a maternal specimen and a prenatal specimen are both required.​​​
​Maternal Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)​Any anticoagulant​3 mL​0.5 mL​
​ ​ ​Prenatal Specimens - submit only 1 of the following specimens:​​​
​Cord Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)​Any anticoagulant​3 mL​0.5 mL​
​Amniotic Fluid​Amniotic fluid container​​20 mL​10 mL​
​Cultured Amniocytes​T-25 flask (submit confluent cultured cells from another laboratory)​​2 full flasks​​
​Chorionic Villi​15-mL tube containing 15 mL of transport media​​20 mg​5 mg​
​Cultured Chorionic Villi​T-25 flask (submit confluent cultured cells from another laboratory)​​2 full flasks​​
Collection Processing Instructions

ORDERING GUIDANCE:

If a prenatal specimen has already been submitted as part of another diagnostic test, a second prenatal specimen is not required. If a prenatal specimen has not yet been submitted, submit only 1 prenatal specimen.

ADDITIONAL TESTING REQUIREMENTS:

A maternal specimen and a prenatal specimen are both required.

-This test must be ordered on both the prenatal and maternal specimens under separate order numbers.

SHIPPING INSTRUCTIONS:

Specimen preferred to arrive within 96 hours of collection.

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Stability Information
Specimen TypeTemperature
​Maternal Blood ​​Ambient (preferred)
​Refrigerated
​Cord Blood ​​Ambient (preferred)
​Refrigerated
​Amniotic Fluid ​​Refrigerated (preferred)
​Ambient
​Cultured Amniocytes ​​Ambient (preferred)
​Refrigerated
​Chorionic Villi​Refrigerated
​Cultured Chorionic Villi ​​Ambient (preferred)
​Refrigerated
Rejection Criteria
All specimens will be evaluated by Mayo Clinic Laboratories for test suitability.
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Batched, performed most weekdays​10 to 11 days​Polymerase Chain Reaction (PCR) based comparison of Microsatellite Markers
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​An interpretive report will be provided.
Interpretation

​An interpretive report will be provided.

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​81265​​1​​
​88233​​1​Fibroblast Culture for Genetic Test​if appropriate
​88240​​1​Fibroblast Culture for Genetic Test​if appropriate
​88235​​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​88240​​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​81266​​​Each additional specimen​
Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Ordering Applications
Ordering ApplicationDescription
​COM​Maternal Cell Contamination, B (MATCC)
​Cerner​Maternal Cell Contam. (MATCC)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​ ​ ​When this test is ordered both a maternal specimen and a prenatal specimen are both required.​​​
​Maternal Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)​Any anticoagulant​3 mL​0.5 mL​
​ ​ ​Prenatal Specimens - submit only 1 of the following specimens:​​​
​Cord Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)​Any anticoagulant​3 mL​0.5 mL​
​Amniotic Fluid​Amniotic fluid container​​20 mL​10 mL​
​Cultured Amniocytes​T-25 flask (submit confluent cultured cells from another laboratory)​​2 full flasks​​
​Chorionic Villi​15-mL tube containing 15 mL of transport media​​20 mg​5 mg​
​Cultured Chorionic Villi​T-25 flask (submit confluent cultured cells from another laboratory)​​2 full flasks​​
Collection Processing

ORDERING GUIDANCE:

If a prenatal specimen has already been submitted as part of another diagnostic test, a second prenatal specimen is not required. If a prenatal specimen has not yet been submitted, submit only 1 prenatal specimen.

ADDITIONAL TESTING REQUIREMENTS:

A maternal specimen and a prenatal specimen are both required.

-This test must be ordered on both the prenatal and maternal specimens under separate order numbers.

SHIPPING INSTRUCTIONS:

Specimen preferred to arrive within 96 hours of collection.

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Stability Information
Specimen TypeTemperature
​Maternal Blood ​​Ambient (preferred)
​Refrigerated
​Cord Blood ​​Ambient (preferred)
​Refrigerated
​Amniotic Fluid ​​Refrigerated (preferred)
​Ambient
​Cultured Amniocytes ​​Ambient (preferred)
​Refrigerated
​Chorionic Villi​Refrigerated
​Cultured Chorionic Villi ​​Ambient (preferred)
​Refrigerated
Rejection Criteria
All specimens will be evaluated by Mayo Clinic Laboratories for test suitability.
Useful For

Ruling out the presence of maternal cell contamination within a fetal specimen

Required for all prenatal testing performed in Mayo Clinic Laboratories' Molecular and Biochemical Genetics laboratories

GENETICS TEST INFORMATION: 

**Required in conjunction with molecular and biochemical prenatal testing only.**

Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​An interpretive report will be provided.
Interpretation

​An interpretive report will be provided.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Batched, performed most weekdays​10 to 11 days​Polymerase Chain Reaction (PCR) based comparison of Microsatellite Markers
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​81265​​1​​
​88233​​1​Fibroblast Culture for Genetic Test​if appropriate
​88240​​1​Fibroblast Culture for Genetic Test​if appropriate
​88235​​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​88240​​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​81266​​​Each additional specimen​
For most current information refer to the Marshfield Laboratory online reference manual.