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26534 N-terminal pro-Brain Natriuretic Peptide

N-terminal pro-Brain Natriuretic Peptide
Test Code: NT-proBNP
Synonyms/Keywords

​​​NT-proBNP

Test Components

​Nt-proBNP

Useful For

​This test is used as an aid in the diagnosis of congestive heart failure.​

Specimen Requirements

Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)

​No
​Plasma/Serum
​Lithium-heparin Plasma Separator Tube (PST)
​Serum Separator Tube (SST), Red Top Tube (RTT)
1.0 mL
0.5 mL​
​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime

​Serum/Plasma
​​

​​

​Ambient
​24 hours
​Refrigerate
​3 days
​Frozen 
​30 days
Rejection Criteria
​Specimens not stored as listed above
Interference

​Specimens that contain biotin at a concentraion of 250 ng/mL demonstrate a less than or equal to 10% change in results. Biotin concentrations greater than this may lead to falsely depressed results for patient samples. Results from patients taking biotin supplements or receiving high-dose biotin therapy should be interpreted with caution due to the possible interference with this test. 

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation

​MMC-Beaver Dam
​Sunday through Saturday
​2 hours
​Chemiluminescent/ Siemens EXL
​MMC-Marshfield
​Sunday through Saturday
​2 hours
​Immunoenzymatic assay/ Beckman Coulter DXI 9000
Reference Range Information
Performing LocationReference Range

​MMC- Beaver Dam
​Patients < 75 years: 125 pg/mL
Patients > or = 75 years: 450 pg/mL​
MMC-Marshfield​​
​Males:
     <50: < = 84 pg/mL
     50-75: < = 188 pg/mL
     >75: < = 243 pg/mL

Females:
     < 50: < = 152 pg/mL
     50-75: < = 282 pg/mL
     >75: < = 443 pg/mL
Interpretation

MMC-Beaver Dam: ​

Diagnostic Criteria:

CHF Unlikely IF:

Age <50 and NT-proBNP <450

Age 50-75 and NT-proBNP <900

Age >75 and NT-proBNP <1800

Pride CHF Score <7


CHF Very likely IF NT-proBNP >10,000 Regardless of age


NT-proBNP should be used as a rule out test for CHF.


*Biotin interference may cause inaccurate results*


MMC-Marshfield:

Diagnostic Criteria:

Age-dependent rule-in cutoffs:

​> = 450 ng/L for subjects < 50 years old

> = 900 ng/L for subjects 50-75 years old

> = 1800 ng/L for subjects > 75 years old

Age-independent rule-out cutoff: < 300 ng/L

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments

​​83880
​​​​
Synonyms/Keywords

​​​NT-proBNP

Test Components

​Nt-proBNP

Ordering Applications
Ordering ApplicationDescription

​Cerner
​​N-terminal pro-Brain Natriuretic Peptide
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements

Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)

​No
​Plasma/Serum
​Lithium-heparin Plasma Separator Tube (PST)
​Serum Separator Tube (SST), Red Top Tube (RTT)
1.0 mL
0.5 mL​
​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime

​Serum/Plasma
​​

​​

​Ambient
​24 hours
​Refrigerate
​3 days
​Frozen 
​30 days
Rejection Criteria
​Specimens not stored as listed above
Interference

​Specimens that contain biotin at a concentraion of 250 ng/mL demonstrate a less than or equal to 10% change in results. Biotin concentrations greater than this may lead to falsely depressed results for patient samples. Results from patients taking biotin supplements or receiving high-dose biotin therapy should be interpreted with caution due to the possible interference with this test. 

Useful For

​This test is used as an aid in the diagnosis of congestive heart failure.​

Test Components

​Nt-proBNP

Reference Range Information
Performing LocationReference Range

​MMC- Beaver Dam
​Patients < 75 years: 125 pg/mL
Patients > or = 75 years: 450 pg/mL​
MMC-Marshfield​​
​Males:
     <50: < = 84 pg/mL
     50-75: < = 188 pg/mL
     >75: < = 243 pg/mL

Females:
     < 50: < = 152 pg/mL
     50-75: < = 282 pg/mL
     >75: < = 443 pg/mL
Interpretation

MMC-Beaver Dam: ​

Diagnostic Criteria:

CHF Unlikely IF:

Age <50 and NT-proBNP <450

Age 50-75 and NT-proBNP <900

Age >75 and NT-proBNP <1800

Pride CHF Score <7


CHF Very likely IF NT-proBNP >10,000 Regardless of age


NT-proBNP should be used as a rule out test for CHF.


*Biotin interference may cause inaccurate results*


MMC-Marshfield:

Diagnostic Criteria:

Age-dependent rule-in cutoffs:

​> = 450 ng/L for subjects < 50 years old

> = 900 ng/L for subjects 50-75 years old

> = 1800 ng/L for subjects > 75 years old

Age-independent rule-out cutoff: < 300 ng/L

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation

​MMC-Beaver Dam
​Sunday through Saturday
​2 hours
​Chemiluminescent/ Siemens EXL
​MMC-Marshfield
​Sunday through Saturday
​2 hours
​Immunoenzymatic assay/ Beckman Coulter DXI 9000
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments

​​83880
​​​​
For most current information refer to the Marshfield Laboratory online reference manual.